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p38 MAPK-IN-1 (Compound 4) is a novel potent and selective inhibitor of p38 MAPK with IC50 of 68 nM. p38 MAPK-IN-1 shows sustained levels, low clearance and good bioavailability.
| Molecular Weight | 349.35 |
| CAS Number | 1006378-90-0 |
| Solubility (25°C) | DMSO 8.33 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Joseph M Grimes, et al. p38 MAPK inhibition: A promising therapeutic approach for COVID-19
[2] Ana Cuadrado, et al. Mechanisms and functions of p38 MAPK signalling
[4] Lydia R Coulthard, et al. p38(MAPK): stress responses from molecular mechanisms to therapeutics
[5] Tyler Zarubin, et al. Activation and signaling of the p38 MAP kinase pathway
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