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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M10442 | Minodronic acid | Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors, Minodronic acid (YM-529) is also a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. |
| M9819 | BAY-1797 | BAY-1797 is a potent and selective, orally active P2X4 antagonist, with IC50 value of 211 nM for human P2X4. |
| M9740 | Aurintricarboxylic acid | Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50 values of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. |
| M9182 | Gefapixant | Gefapixant, also known as AF-219 or MK-7264, is a P2X3 receptor antagonist. |
| M6374 | A 804598 | A 804598 is a potent and selective P2X7 antagonist. |
| M6347 | 5-BDBD | 5-BDBD is a potent P2X4 receptor antagonist. |
| M5986 | Suramin sodium salt | Suramin sodium salt is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 μM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors (10-100 μM). |
| M5023 | Clopidogrel hydrogen sulfate | S-(+)-Clopidogrel Hydrogen Sulfate is the S enantiomer of clopidogrel and a P2Y12 receptor inhibitor. |
| M3280 | Clopidogrel | Clopidogrel (Plavix) is an oral, thienopyridine class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. |
| M3233 | GW791343 trihydrochloride | GW791343 trihydrochloride is ahydrochloride salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7. |
| M3185 | Ticlopidine hydrochloride | Ticlopidine hydrochloride is a selective P2Y12 receptor antagonist. |
| M3069 | Ticagrelor | Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist with Ki of 2 nM respectively. |
| M2954 | PPADS Tetrasodium Salt | PPADS tetrasodium salt is a non-selective P2 purinergic antagonist blocking recombinant P2X1, P2X2, P2X3, P2X5 with IC50 of 1-2.6 μM, native P2Y2-like with IC50 of ~ 0.9 mM, and recombinant P2Y4 receptors with IC50 of ~ 15 mM |
| M2869 | MRS 2578 | MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors. |
| M2234 | Prasugrel | Prasugrel is a platelet inhibitor irreversibly binding to P2Y12 receptors. |
| M1909 | GW 791343 dihydrochloride | GW 791343 dihydrochloride is a non-competitive inhibitor of human P2X(7) receptor. |
| M1895 | Prasugrel hydrochloride | Prasugrel hydrochloride is a novel inhibitor of platelet activation and aggregation. |
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