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Oleoyl-L-α-lysophosphatidic acid sodium salt

Cat. No. M10485
Oleoyl-L-α-lysophosphatidic acid sodium salt Structure
Synonym:

Oleoyl LPA sodium

Size Price Availability Quantity
1mg USD 135  USD135 In stock
5mg USD 250  USD250 In stock
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Quality Control & Documentation
Biological Activity

Oleoyl-L-α-lysophosphatidic acid (LPA) sodium salt is a ligand for P2Y5.

Chemical Information
Molecular Weight 430.45
Formula C19H36NaO7P
CAS Number 22556-62-3
Solubility (25°C) Water 5 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Saima Younis, et al. PLoS One. Alpha conotoxin-BuIA globular isomer is a competitive antagonist for oleoyl-L-alpha-lysophosphatidic acid binding to LPAR6; A molecular dynamics study

[2] Sandra M Pasternack, et al. Nat Genet. G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

[3] Sungwon Choi, et al. Am J Physiol Gastrointest Liver Physiol. Identification of a protein hydrolysate responsive G protein-coupled receptor in enterocytes

[4] Donna M Peters, et al. Exp Cell Res. Myocilin binding to Hep II domain of fibronectin inhibits cell spreading and incorporation of paxillin into focal adhesions

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Keywords: Oleoyl-L-α-lysophosphatidic acid sodium salt, Oleoyl LPA sodium supplier, P2 Receptor, inhibitors, activators


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