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BAY-1797

Cat. No. M9819
BAY-1797 Structure
Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 160  USD160 In stock
25mg USD 350  USD350 In stock
50mg USD 600  USD600 In stock
100mg USD 1050  USD1050 In stock
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Quality Control & Documentation
Biological Activity

BAY-1797 is a potent and selective, orally active P2X4 antagonist, with IC50 value of 211 nM for human P2X4. BAY-1797 inhibits human, mouse, and rat P2X4 in 1321N1 cells with IC50 values of 108 nM, 112 nM, and 233 nM, respectively.

Chemical Information
Molecular Weight 416.88
Formula C20H17ClN2O4S
CAS Number 2055602-83-8
Solubility (25°C) DMSO ≥ 120 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Stefan Werner, et al. J Med Chem. Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile

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  Catalog
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Keywords: BAY-1797 supplier, P2 Receptor, inhibitors, activators


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