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JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively.
| Molecular Weight | 440.78 |
| Formula | C18H13ClF4N6O |
| CAS Number | 1627902-21-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 62.5 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related P2 Receptor Products |
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| NF449
NF449 is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. |
| NF279
NF279 is a potent selective and reversible P2X1 receptor antagonist, with an IC50 of 19 nM. |
| NF110
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| PSB-12062
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| NF449 octasodium
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