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A 438079 hydrochloride

Cat. No. M11482
A 438079 hydrochloride  Structure
Synonym:

A-438079 HCl

Size Price Availability Quantity
10mg USD 122  USD122 In stock
50mg USD 380  USD380 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

A 438079 Hydrochloride is A potent, selective P2X7 receptor antagonist with A pIC50 of 6.9.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 342.611
Formula C13H10Cl3N5
CAS Number 899431-18-6
Purity >99%
Solubility DMSO ≥ 40 mg/mL
Storage 4°C , dry , sealed
References

[1] Juliang Qin, et al. Cancer Immunol Res. Blocking P2X7-Mediated Macrophage Polarization Overcomes Treatment Resistance in Lung Cancer

[2] Jess Snchez-Nogueiro, et al. Eur J Pharmacol. Subcellular distribution and early signalling events of P2X7 receptors from mouse cerebellar granule neurons

[3] Kimiko Kobayashi, et al. Neurosci Lett. Induction of the P2X7 receptor in spinal microglia in a neuropathic pain model

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