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Minodronic acid

Cat. No. M10442
Minodronic acid Structure
Synonym:

YM-529; ONO-5920; YH-529

Size Price Availability Quantity
10mg USD 50  USD50 In stock
50mg USD 140  USD140 In stock
100mg USD 230  USD230 In stock
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Quality Control & Documentation
Biological Activity

Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors, Minodronic acid (YM-529) is also a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells.

Chemical Information
Molecular Weight 322.15
Formula C9H12N2O7P2
CAS Number 180064-38-4
Solubility (25°C) Water 3 mg/mL (May need adjust pH)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Makoto Tanaka, et al. J Bone Miner Metab. Minodronic acid induces morphological changes in osteoclasts at bone resorption sites and reaches a level required for antagonism of purinergic P2X2/3 receptors

[2] Jun Iwamoto, et al. Bone. Effect of combined teriparatide and monthly minodronic acid therapy on cancellous bone mass in ovariectomized rats: a bone histomorphometry study

[3] K Sato, et al. Br J Cancer. A third-generation bisphosphonate, minodronic acid (YM529), successfully prevented the growth of bladder cancer in vitro and in vivo

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Keywords: Minodronic acid, YM-529; ONO-5920; YH-529 supplier, P2 Receptor, inhibitors, activators


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