| Cat.No. | Name | Information |
|---|---|---|
| M40489 | BQ-3020 ammonium | BQ-3020 ammonium is an endothelin receptor ETB agonist and induces endothelium-dependent vasodilation, which can be used in studies related to cardiovascular disease. |
| M28815 | IRL 2500 | IRL 2500 is a potent Endothelin receptor antagonist. IRL 2500 shows IC50 values of 1.3 and 94 nM for ETB and ETA receptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo. |
| M25449 | IRL-1620 TFA | IRL-1620 TFA is a potent and selective endothelin receptor type B (ETB) agonist with a Ki of 16 pM. |
| M21788 | Atrasentan | Atrasentan is a selective, orally active endothelin A (ETA) receptor antagonist. It can be used in studies related to glomerular disease and diabetic nephropathy. |
| M20689 | Sparsentan (RE-021) | Sparsentan (PS-433540, RE-021, DARA) is a first-in-class, orally active, high-affinity dual antagonist of the endothelin type A receptor (ETA) and Angiotensin II type 1 (AT1) receptor, with Ki values of 9.3 and 0.8 nM, respectively. |
| M13959 | BQ-788 sodium salt | BQ-788 sodium salt is an effective and selective ETB receptor antagonist with an IC50 of 1.2 nM in human Girrardi heart cells to inhibit ET-1 binding to the ETB receptor. BQ-788 is an enhancer of AQP4(Aquaporin-4). |
| M13958 | BQ-788 | BQ-788 is a potent and selective ETB receptor antagonist with an IC50 of 1.2 nM inhibiting ET-1 binding to ETB receptor in human Girrardi heart cells. BQ-788 is an enhancer of AQP4(Aquaporin-4). |
| M13957 | Carperitide acetate | Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. |
| M13956 | Aprocitentan | Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. |
| M10916 | RO 46-8443 | RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. |
| M9792 | Sarafotoxin S6c | Sarafotoxin S6c is a highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively). |
| M9555 | Endothelin-1 (human, porcine) | Endothelin-1 (human, porcine) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. |
| M9554 | BQ-123 | BQ-123 is a selective endothelin A receptors (ETAR) antagonist with an IC50 value of 7.3 nM. |
| M8766 | Atrasentan hydrochloride | Atrasentan hydrochloride (ABT-627 hydrochloride) is a potent, orally active, selective endothelin A (ETA) receptor antagonist that inhibits ETA activity and blocks endothelin-induced cellular proliferation with an IC50 value of 0.0551 nM. It can be used in studies related to prostate cancer as well as IgA nephropathy (IgAN). It can be used in prostate cancer and IgA nephropathy (IgAN) related studies. |
| M5135 | Ro-46-2005 | Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM. |
| M3388 | Sulfisoxazole | Sulfisoxazole is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole (Sulfafurazole) is an orally active endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A. |
| M2467 | Bosentan | Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. |
| M2278 | Bosentan Hydrate | Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. |
| M2205 | Macitentan | Macitentan is an orally-active, tissue-targeting dual ET receptor antagonist. |
| M2029 | Sitaxsentan sodium | Sitaxsentan (TBC-11251) is an orally active, highly selective antagonist of endothelin A receptors. |
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