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Endothelin-1 (human, porcine) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin-1 acts through two types of receptors ETA and ETB. ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion.
Sci Rep. 2025 Feb 15;15(1):5626.
Identification of ECE2 signaling in promoting non-small lung cancer progression through ET1/YAP1/MAGEA3 axis
Endothelin-1 (human, porcine) purchased from AbMole
Cytotherapy. 2024 Jul 24.
Human neural stem cells transplanted during the sequelae phase alleviate motor deficits in a rat model of cerebral palsy
Endothelin-1 (human, porcine) purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | Cardiomyocytes |
| Preparation method | Cardiomyocytes were cultured in 24-well culture plates. Twelve hours after the addition of rotenone (1 μM), endothelin-1 (10 nM) or vehicle was added to the medium. Concomitantly, 37 kBq of 2-deoxyglucose solution was added to the culture medium. The cells were incubated for 7 h. Then, the medium was aspirated, and the cells were washed twice with ice-cold phosphate-buffered saline. |
| Concentrations | 10 nM |
| Incubation time | 7 h |
| Animal Experiment | |
|---|---|
| Animal models | Male Swiss mice |
| Formulation | PBS |
| Dosages | 1 to 30 pmol/paw (20 μL) |
| Administration | i.pl. injection |
| Molecular Weight | 2491.9 |
| Formula | C109H159N25O32S5 |
| CAS Number | 117399-94-7 |
| Solubility (25°C) | Soluble in water |
| Storage | -20°C, dry, protect from light, sealed |
| Related Endothelin Receptor Products |
|---|
| Zibotentan
Zibotentan (ZD4054) is a more selective and specific endothelin-A receptor (ETAR) antagonist with an IC50 value of 21 nM. |
| Sitaxsentan sodium
Sitaxsentan (TBC-11251) is an orally active, highly selective antagonist of endothelin A receptors. |
| Macitentan
Macitentan is an orally-active, tissue-targeting dual ET receptor antagonist. |
| Sulfisoxazole
Sulfisoxazole is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole (Sulfafurazole) is an orally active endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A. |
| Ro-46-2005
Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM. |
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Products are for research use only. Not for human use. We do not sell to patients.
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