All AbMole products are for research use only, cannot be used for human consumption.
IRL-1620 TFA is a potent and selective endothelin receptor type B (ETB) agonist with a Ki of 16 pM. IRL-1620 TFA (1-100 nM) increases cytosolic Ca2+ in the vascular endothelium with little effect on resting muscle tone, and relaxes the norepinephrine-stimulated tone.
IRL-1620 TFA (1-100 nM) induces contractions of the guinea pig trachea. Rats treated with IRL-1620 significantly reduces the cognitive impairment induced by Aβ.
| Molecular Weight | 1934.97 |
| Formula | C88H118F3N17O29 |
| CAS Number | 142569-99-1 (free base) |
| Solubility (25°C) | DMSO 50 mg/mL (Need ultrasonic) |
| Storage | Store at ≤ -20°C, protect from light, dry, sealed |
| Related Endothelin Receptor Products |
|---|
| A-127722
A-127722 is A 2, 4-dialarylpyrrolidine-3-carboxylic acid ETA selective endothelin receptor (ET receptor) antagonist with IC50 value of 0.36 nM. |
| Endothelin 1 (swine, human) (TFA)
Endothelin 1 (swine, human) (TFA) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. |
| Atrial Natriuretic Peptide (ANP) (1-28), rat
Atrial Natriuretic Peptide (ANP) (1-28), rat is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner. |
| [Asn18] Endothelin-1, human
[Asn18] Endothelin-1, human is a peptide. |
| [Lys4] Sarafotoxin S6c
[Lys4] Sarafotoxin S6c, a sarafotoxin analogue, is a potent and partial agonist of endothelin receptor. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
