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Atrasentan hydrochloride (ABT-627 hydrochloride) is a potent, orally active, selective endothelin A (ETA) receptor antagonist that inhibits ETA activity and blocks endothelin-induced cellular proliferation with an IC50 value of 0.0551 nM. It can be used in studies related to prostate cancer as well as IgA nephropathy (IgAN). It can be used in prostate cancer and IgA nephropathy (IgAN) related studies.
| Molecular Weight | 547.08 |
| Formula | C29H38N2O6 · HCl |
| CAS Number | 195733-43-8 |
| Solubility (25°C) | DMSO: 2 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Jesus Egido, et al. Atrasentan for the treatment of diabetic nephropathy
[4] A Kalliokoski, et al. Impact of OATP transporters on pharmacokinetics
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