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CSF-1R (c-Fms) Colony stimulating factor 1 receptor (c-Fms)

Cat.No.  Name Information
M5316 BLZ945 (Sotuletinib) Sotuletinib (BLZ945) is an orally active, potent and selective CSF-1R inhibitor with IC50 of 1 nM, >1000-fold selective against its closest receptor tyrosine kinase homologs.
M2743 GW2580 GW2580 is a selective CSF-1R inhibitor for c-FMS with IC50 of 30 nM, 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2 etc.
M43482 Pimicotinib Pimicotinib is a novel, orally bioavailable, highly selective small-molecule inhibitor of colony-stimulating factor 1 (CSF-1) with antitumor activity and less inhibitory effects on c-Kit and PDGFR.
M43479 Sotuletinib hydrochloride Sotuletinib (BLZ945) hydrochloride is a potent, selective and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC50 of 1 nM.
M24957 Axatilimab Axatilimab (SNDX-6352) is a humanized IgG4 antibody with high affinity to CSF-1R. Axatilimab can be used for the research of chronic graft versus host disease (cGVHD) and neoplastic diseases.
M11516 Vimseltinib Vimseltinib (DCC-3014) is a highly selective, orally active inhibitor of colony-stimulating factor-1 receptor (CSF-IR) and c-Kit with IC50 values of <0.01 μM and 0.1-1 μM, respectively.Vimseltinib is used in studies related to tenosynovial giant cell tumors (TGCT).
M10938 AZD7507 AZD7507 is a potent, oral CSF-1R inhibitor with antitumor activity.
M10937 Edicotinib Edicotinib (JNJ-40346527) is a potent, selective, blood-brain permeable and orally active CSF-1R inhibitor.IC50 3.2 nM. Edicotinib has less inhibitory effect on KIT and FLT3,IC50 The values are 20 nM and 190 nM, respectively. Edicotinib inhibits the expansion of microglia, weakens the proliferation of microglia and neurodegenerative degeneration. Edicotinib can be used in the study of Alzheimer's disease and rheumatoid arthritis.
M9685 cFMS Receptor Inhibitor II cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor.
M9512 PLX5622 PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM.
M6865 Ki 20227 Ki 20227 is a c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation.
M4955 PLX647 PLX647 is a highly specific dual FMS/KIT kinase inhibitor with IC50 of 28/16 nM respectively.
M43943 Tinengotinib Tinengotinib is a modulator of several protein kinases, such as Aurora kinase, VEGFR kinase, and CSF-1R, etc. Tinengotinib can be used in studies related to diseases mediated by abnormalities in these kinases.
M43942 AMG-820 AMG-820 is an anti-colony stimulating factor 1 receptor (CSF1R) monoclonal antibody.
M43483 CSF1R-IN-15 CSF1R-IN-15 is an inhibitor targeting CSF1R.
M43481 c-Fms-IN-14 c-Fms-IN-14 is a c-Fms inhibitor with an IC50 value of 4 nM.
M43480 CSF1R-IN-17 CSF1R-IN-17 is a potent and selective CSF1R antagonist, with an IC50 of 0.2 nM.
M29163 GENZ-882706 GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) inhibitor.
M28057 JTE-952  JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis.
M25133 Anumigilimab Anumigilimab (CSL-324) is an humanized IgG2a mAb against human granulocyte colony-stimulating factor (G-CSF) receptor. Anumigilimab can be used for increasing numbers of neutrophils at sites of inflammation.

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