Free shipping on all orders over $ 500

PLX5622

Cat. No. M9512
PLX5622 Structure
Synonym:

PLX5622 free base; PLX-5622

Size Price Availability Quantity
1mg USD 45 In stock
5mg USD 115 In stock
10mg USD 185 In stock
25mg USD 375 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM. PLX5622 eliminates microglia from the brain, which can be sustained in wild-type and the Alzheimer's disease model mice (3xTg-AD model). In the AD model PLX5622 prevents microglial association with amyloid β plaques and improves cognition.

In vivo, PLX5622 (65 mg/kg/day; oral gavage for 14 days) causes paw withdrawal threshold high in mice, indicating that PLX5622 prevents the development of injury-associated mechanical allodynia.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 395.41
Formula C21H19F2N5O
CAS Number 1303420-67-8
Purity 100.0%
Solubility DMSO ≥ 65 mg/mL
Storage at -20°C
References

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.
Spangenberg E, et al. Nat Commun. 2019 Aug 21;10(1):3758. PMID: 31434879.

Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain.
Lee S, et al. Mol Pain. 2018 Jan-Dec;14:1744806918764979. PMID: 29546785.

Related CSF-1R Products
cFMS Receptor Inhibitor II

cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor.

BLZ945

BLZ945 is an orally active, potent and selective CSF-1R inhibitor with IC50 of 1 nM, >1000-fold selective against its closest receptor tyrosine kinase homologs.

GW2580

GW2580 is a selective CSF-1R inhibitor for c-FMS with IC50 of 30 nM, 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2 etc.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PLX5622, PLX5622 free base; PLX-5622 supplier, CSF-1R, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.