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Cat. No. M9512
PLX5622 Structure

PLX5622 free base; PLX-5622

Size Price Availability Quantity
1mg USD 45 In stock
5mg USD 115 In stock
10mg USD 185 In stock
25mg USD 375 In stock
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Quality Control
Biological Activity

PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM. PLX5622 eliminates microglia from the brain, which can be sustained in wild-type and the Alzheimer's disease model mice (3xTg-AD model). In the AD model PLX5622 prevents microglial association with amyloid β plaques and improves cognition.

In vivo, PLX5622 (65 mg/kg/day; oral gavage for 14 days) causes paw withdrawal threshold high in mice, indicating that PLX5622 prevents the development of injury-associated mechanical allodynia.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 395.41
Formula C21H19F2N5O
CAS Number 1303420-67-8
Purity 100.0%
Solubility DMSO ≥ 65 mg/mL
Storage at -20°C

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.
Spangenberg E, et al. Nat Commun. 2019 Aug 21;10(1):3758. PMID: 31434879.

Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain.
Lee S, et al. Mol Pain. 2018 Jan-Dec;14:1744806918764979. PMID: 29546785.

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Abmole Inhibitor Catalog 2017

Keywords: PLX5622, PLX5622 free base; PLX-5622 supplier, CSF-1R, inhibitors

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