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cFMS Receptor Inhibitor II

Cat. No. M9685
cFMS Receptor Inhibitor II Structure
Size Price Availability Quantity
2mg USD 179 In stock
5mg USD 347 In stock
10mg USD 545 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 368.43
Formula C23H20N4O
CAS Number 959860-85-6
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
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BLZ945

BLZ945 is an orally active, potent and selective CSF-1R inhibitor with IC50 of 1 nM, >1000-fold selective against its closest receptor tyrosine kinase homologs.

GW2580

GW2580 is a selective CSF-1R inhibitor for c-FMS with IC50 of 30 nM, 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2 etc.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: cFMS Receptor Inhibitor II supplier, CSF-1R, inhibitors

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