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Sotuletinib (BLZ945) hydrochloride is a potent, selective and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC50 of 1 nM.
| Molecular Weight | 434.94 |
| Formula | C20H23ClN4O3S |
| CAS Number | 2222138-31-8 |
| Form | Solid |
| Solubility (25°C) | Water 100 mg/mL (Need ultrasonic) DMSO 100 mg/mL (Need ultrasonic) |
| Storage | 4°C, dry, sealed |
| Related CSF-1R (c-Fms) Products |
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| ARRY-382
ARRY-382 is a potent, oral and highly selective inhibitor of CSF1R/c-Fms with an IC50 of 9 nM. |
| Tinengotinib
Tinengotinib is a modulator of several protein kinases, such as Aurora kinase, VEGFR kinase, and CSF-1R, etc. Tinengotinib can be used in studies related to diseases mediated by abnormalities in these kinases. |
| AMG-820
AMG-820 is an anti-colony stimulating factor 1 receptor (CSF1R) monoclonal antibody. |
| CSF1R-IN-15
CSF1R-IN-15 is an inhibitor targeting CSF1R. |
| Pimicotinib
Pimicotinib is a novel, orally bioavailable, highly selective small-molecule inhibitor of colony-stimulating factor 1 (CSF-1) with antitumor activity and less inhibitory effects on c-Kit and PDGFR. |
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