Free shipping on all orders over $ 500

GW2580

Cat. No. M2743
GW2580 Structure
Synonym:

SC-203877

Size Price Availability Quantity
50mg USD 90 In stock
100mg USD 120 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

GW2580 is a selective CSF-1R inhibitor for c-FMS with IC50 of 30 nM, 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2 etc.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 366.41
Formula C20H22N4O3
CAS Number 870483-87-7
Purity 100.0%
Solubility DMSO 28 mg/mL
Storage at -20°C
References

Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580
James G Conway, et al. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16078-83. PMID: 16249345.

Related CSF-1R Products
cFMS Receptor Inhibitor II

cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor.

PLX5622

PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM.

BLZ945

BLZ945 is an orally active, potent and selective CSF-1R inhibitor with IC50 of 1 nM, >1000-fold selective against its closest receptor tyrosine kinase homologs.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: GW2580, SC-203877 supplier, CSF-1R, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.