About 30 results found for searched term "W-13" (0.036 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M45166 | LWY713 | PROTAC |
| LWY713 is a PROTAC molecule targeting FLT3 with acetyl group as linker, which can selectively induce FLT3 degradation in CRBN and proteasome-dependent manner, with a DC50 of 0.64 nM and a Dmax of 94.8%, and possesses antitumor activity. | ||
| M1754 | WP1130 | JAK |
| Degrasyn | ||
| Degrasyn (WP1130) is a small molecular deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway. | ||
| M1909 | GW 791343 dihydrochloride | P2 Receptor |
| GW 791343 dihydrochloride is a non-competitive inhibitor of human P2X(7) receptor. | ||
| M2555 | AWD 131-138 | GABA Receptor |
| Imepitoin | ||
| AWD 131-138 is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models. | ||
| M3233 | GW791343 trihydrochloride | P2 Receptor |
| GW791343 trihydrochloride is ahydrochloride salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7. | ||
| M3556 | WYE-125132 | mTOR |
| WYE-125132 is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR. | ||
| M3722 | Temsirolimus | mTOR |
| CCI-779; WAY-130779 | ||
| Temsirolimus (WAY-130779, CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM. | ||
| M8991 | Dilmapimod | p38 MAPK |
| SB-681323; GW-681323 | ||
| Dilmapimod (also known as SB-681323 and GW-681323) is a p38 MAPK inhibitor that potentially suppresses inflammation in COPD. | ||
| M5028 | JANEX-1 | JAK |
| WHI-P131 | ||
| Janex-1 is a cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (IC50 = 78 μM); has no effect on JAK1, JAK2, or Zap/Syk or SRC tyrosine kinases. | ||
| M8407 | W-13 | Others |
| W-13 has also been shown to inhibit the transcytosis of IgA, recycling of transferrin and overall alter the endocytic pathway in Madin-Darby canine kidney cells. | ||
| M8465 | WWL113 | Others |
| WWL113 is an inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3), serine hydrolases involved in lipolysis in addition to their activities as liver detoxification enzymes. | ||
| M8850 | WAY-213613 | EAAT |
| Way-213613 is a potent, selective, non-substrate reuptake inhibitor of GLT-1/EAAT2 with an IC50 of 85 nM against EAAT2. The selectivity of WAY-213613 hydrochloride to EAAT1 and EAAT3 was 59 and 44 times higher (IC50 was 5 and 3.8 μM, respectively). Way-213613 has no activity on ionic and metabolic glutamate receptors. | ||
| M8856 | WAY-100135 dihydrochloride | 5-HT Receptor |
| WAY-100135 dihydrochloride is a potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). | ||
| M11390 | Recombinant Human 4-1BB Protein (HEK293) | Cytokines and Growth Factors |
| TNFRSF9、4-1BB、CD137、CDw137、ILA | ||
| Recombinant Human 4-1BB Protein (HEK293) Protein sequence: DNA sequence encoding human 4-1BB (UniProtKB/ Swiss-PROt: Q07011.1) expressed with His tag at the C-terminal Bioactivity: 4-1BB, also known as CD137, is a member of the tumor necrosis factor receptor superfamily 9 (TNFRSF9) induced by lymphocyte activation (ILA), and is a costimulatory molecule of the tumor necrosis factor receptor superfamily. | ||
| M14213 | WAY-213613 hydrochloride | EAAT |
| WAY-213613 hydrochloride is a potent, selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 with IC50 of 85 nM EAAT2. | ||
| M20027 | WAY-113178 | IκB/IKK |
| WAY-113178 is a IkB kinase-beta (IKKb) inhibitor. | ||
| M20034 | WAY-248134 | Others |
| WAY-248134 is a LIMK1 inhibitor | ||
| M20045 | WAY-271413 | GSK-3 |
| WAY-271413 is a GSK-3β inhibitor. | ||
| M20048 | WAY-272130 | FGFR |
| WAY-272130 is a FGFR1 inhibitor. | ||
| M20082 | WAY-313013 | p38 MAPK |
| WAY-313013 is a p38a Mitogen-Activated Protein Kinase inhibitor | ||
| M20083 | WAY-313218 | Others |
| WAY-313218 is a 11β-hydroxysteroid dehydrogenase type 1 modulator | ||
| M20093 | WAY-321364 | Casein Kinase |
| WAY-321364 altering the lifespan of a eukaryotic organism | ||
| M20094 | WAY-321366 | Others |
| WAY-321366 is a abelson tyrosine kinase inhibitor | ||
| M20187 | WAY-601323 | CDK |
| WAY-601323 is a Mimetic CDK9 inhibitor. | ||
| M20208 | WAY-613473 | HIV Protease |
| WAY-613473 has inhibition of HIV-I replication | ||
| M20209 | WAY-613991 | Casein Kinase |
| WAY-613991 is a Casein kinase 1d inhibitor | ||
| M20233 | WAY-632613 | p38 MAPK |
| WAY-632613 is a p38 MAP Kinase inhibitor. | ||
| M20266 | WAY-650313 | Casein Kinase |
| WAY-650313 is a Casein kinase 1δ inhibitor. | ||
| M20280 | WAY-658513 | ROCK |
| WAY-658513 is a inhibitor of ROCK, ERK, GSK, and AGC protein kinases. | ||
| M20301 | WAY-613982 | Others |
| WAY-613982 is a CK2 inhibitor. | ||
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