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JANEX-1

Cat. No. M5028
JANEX-1 Structure
Synonym:

WHI-P131

Size Price Availability Quantity
10mM*1mL USD 99  USD110 In stock
5mg USD 90  USD100 In stock
10mg USD 162  USD180 In stock
50mg USD 540  USD600 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

The incidence of diabetes at 25 weeks was only 9% for NOD females treated with daily injections of JANEX-1 (100 mg/kg/day) from Week 10 through Week 25 (P = 0.007). Furthermore, JANEX-1 prevented the development of insulitis and diabetes in NOD-scid/scid females after adoptive transfer of splenocytes from diabetic NOD females.The antigen-induced degranulation and activation of MAPKs were inhibited by WHI-P131 and WHI-P154 in both groups of BMMCs, indicating that these compounds inhibit a certain step except for Jak3. The antigen-induced increase in the activity of Fyn, a probable tyrosine kinase of Gab2, was also inhibited by WHI-P131 and WHI-P154 in RBL-2H3 cells.

Customer Product Validations & Biological Datas
Source PLoS One (2016). Figure 1. JANEX-1
Method flow cytometry
Cell Lines human blood T lymphocytes
Concentrations 80 μM
Incubation Time 5, 24 or 48 h
Results Both PP2 and WHI-P131decreased the number of CD25+ cells in PHA-induced cultures, reduced the S-phase induction and suppressed the growth of activated PBL
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 297.31
Formula C16H15N3O3
CAS Number 202475-60-3
Purity >98%
Solubility DMSO:~1 mg/ml
Storage at -20°C
References

Inhibition of the antigen-induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner.
Linwong W,et.al. Br J Pharmacol. 2005 Jul;818-28. PMID: 15852029.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: JANEX-1, WHI-P131 supplier, JAK, inhibitors

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