About 26 results found for searched term "SA-PA" (0.072 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2151 | INK128 (Sapanisertib) | mTOR |
| MLN0128; TAK-228 | ||
| INK128 (Sapanisertib; MLN0128) is a potent and selective dual TORC1/2 inhibitor with IC50 of 1 nM. | ||
| M4067 | Ginsenoside-Rg2 | NF-κB |
| Chikusetsusaponin I; Panaxoside Rg2; Prosapogenin C2 | ||
| Ginsenoside-Rg2 is one of the major active components of ginseng, acts as a NF-κB inhibitor. | ||
| M4490 | Protosappanin-B | Apoptosis |
| Protosappanin B is a polyphenol substance extracted from Sappanwood, which has anti-tumor effect. In human bladder cancer cells, it can induce apoptosis by arresting G1 phase of cell cycle. | ||
| M8261 | TVP1022 | Monoamine Transporter |
| (S)-Rasagiline; S-PAI | ||
| TVP1022, an S isomer of Rasagiline, an anti-Parkinson's compound, appears to have the same neuroprotective activity as r isomer, but is 1000 times more active as an inhibitor of MAO-B. | ||
| M9962 | Nonivamide | TRP Channel |
| Capsaicin; Pelargonic acid vanillylamide; PAVA | ||
| Nonivamide (also called pelargonic acid vanillylamide or PAVA) can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A. | ||
| M10298 | AZD5305 | PARP |
| Saruparib; AZD-5305 | ||
| Saruparib (AZD5305) is a potent and oral active, second-generation PARP (highly selective PARP1) inhibitor with IC50 values of 3 nM and 1400 nM for PARP1 and PARP2, respectively. | ||
| M10696 | Protosappanin A | JAK |
| 原苏木素A; PTA | ||
| Protosappanin A (PTA), an immune agent, is a major biphenyl compound isolated from Caesalpinia sappan L that inhibits the JAK2/STAT3-dependent inflammatory pathway by down-regulating the phosphorylation of JAK2 and STAT3. | ||
| M14737 | N-Bis(2-hydroxypropyl)nitrosamine | Others |
| DHPN; Di(2-hydroxypropyl)nitrosamine; Diisopropanolnitrosamine | ||
| N-Bis(2-hydroxypropyl)nitrosamine is an agent with carcinogenic activity. | ||
| M17135 | Desacetylripariochromene B | Phenols |
| Desacetylripariochromene B | ||
| M19176 | Sappanone A | NF-κB |
| Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. | ||
| M21178 | TAK-653 | GluR |
| Osavampator | ||
| Osavampator (TAK-653) is a potential first-in-class alpha amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) enhancer. | ||
| M24733 | Tabituximab barzuxetan | Wnt/beta-catenin |
| OTSA101-DTPA; OTSA101-DTPA-90Y; OTSA101-SS01 | ||
| Tabituximab barzuxetan (OTSA101-DTPA-90Y) is a radioimmunoconjugate composed of a humanized monoclonal antibody targeting FZD-10 (OTSA-101), and labeled with Yttrium 90. Tabituximab barzuxetan shows antineoplastic activity. Tabituximab barzuxetan can be used for synovial sarcoma research. | ||
| M25290 | Topsalysin | Others |
| PRX-302; PRX302 PSA-PAH1 | ||
| Topsalysin (PRX-302; PRX302; PSA-PAH1) is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle. | ||
| M27815 | 3-Deoxysappanchalcone | Anti-infection |
| 3-Deoxysappanchalcone is a naturally-occurring chalcone compound isolated from Caesalpinia sappan L. (Leguminosae), which possesses anti-allergic, antiviral, anti-inflammatory and antioxidant activities. 3-Deoxysappanchalcone exerts anti-inflammatory activity via induce heme oxygenase-1 (HO-1) expression by activating the AKT/mTOR pathway in murine macrophages. 3-Deoxysappanchalcone also exhibits anti-influenza virus activity (H3N2, IC50 = 1.06 μM). | ||
| M28134 | Sampatrilat | ACE |
| UK-81252 | ||
| Sampatrilat (UK-81252) is a potent and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase (NEP). Sampatrilat inhibits C-domain ACE (Ki=13.8 nM) 12.4-fold more potent than that for the N-domain (Ki=171.9 nM). Sampatrilat (UK-81252) can be used for the study of chronic heart failure and blood pressure regulation. | ||
| M28560 | Sapacitabine | Nucleoside Antimetabolite/Analog |
| CS682; CYC682 | ||
| Sapacitabine is an orally available nucleoside analog proagent that is structurally related to cytarabine. | ||
| M38720 | 4-O-Methylsappanol | Antifungal |
| 4-O-Methylsappanol is a natural isoflavonoid with antifungal activities. 4-O-Methylsappanol shows activity against Beauveria bassiana. 4-O-Methylsappanol (EC50 of 4.6 μM) strongly suppresses Melanin (Melanin) synthesis in HMV-II cells. | ||
| M38833 | Sappanchalcone | Apoptosis |
| Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells. | ||
| M38857 | Episappanol | TNF Receptor |
| Episappanol is a natural compound isolated from Caesalpinia sappan heartwood with anti-inflammatory activity. Episappanol significantly inhibits the IL-6 and TNF-α secretion. | ||
| M39015 | Deoxysappanone B | p38 MAPK |
| Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage. | ||
| M39719 | 12-Hydroxysapriparaquinone | Others |
| 12-Hydroxysapriparaquinone (compound 8) is a rearranged 4,5-seco-abietane diterpenoid isolated from the petroleum ether extract of the root of Salvia rhytidea. | ||
| M40034 | Caesappanin C | Others |
| Caesappanin C, a biphenyl dimer from the ethanolic extract of the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro. Caesappanin C has the potential to stimulate bone formation and regeneration. | ||
| M42625 | Protosappanin A dimethyl acetal | Xanthine Oxidase |
| Protosappanin A dimethyl acetal is a homoisoflavonoid. | ||
| M43451 | SA-PA | PROTAC |
| SA-PA is an intracellular self-assembled PROTAC based on azide and alkyne. | ||
| M43730 | 14-Benzoylmesaconine-8-palmitate | Others |
| 14-Benzoylmesaconine-8-palmitate is a lipo-alkaloid compound that can be found in A. | ||
| M55806 | Bersacapavir | Anti-infection |
| Bersacapavir is a novel Hepatitis B Virus capsid assembly modulator. | ||
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