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Sampatrilat

Cat. No. M28134

All AbMole products are for research use only, cannot be used for human consumption.

Sampatrilat Structure
Synonym:

UK-81252

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Quality Control & Documentation
Biological Activity

Sampatrilat (UK-81252) is a potent and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase (NEP). Sampatrilat inhibits C-domain ACE (Ki=13.8 nM) 12.4-fold more potent than that for the N-domain (Ki=171.9 nM). Sampatrilat (UK-81252) can be used for the study of chronic heart failure and blood pressure regulation.

Chemical Information
Molecular Weight 584.68
Formula C26H40N4O9S
CAS Number 129981-36-8
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Urvashi Sharma, et al. J Med Chem. Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin-Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme

[2] Gyles E Cozier, et al. FEBS J. Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE - a molecular basis for domain selectivity

[3] Rajni K Sharma, et al. J Chem Inf Model. The Dynamic Nonprime Binding of Sampatrilat to the C-Domain of Angiotensin-Converting Enzyme

[4] Kristina Allikmets. Curr Opin Investig Drugs. Sampatrilat Shire

[5] No authors listed. Drugs R D. Sampatrilat. UK 81252

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Keywords: Sampatrilat, UK-81252 supplier, ACE, inhibitors, activators

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