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3-Deoxysappanchalcone 

Cat. No. M27815

All AbMole products are for research use only, cannot be used for human consumption.

3-Deoxysappanchalcone  Structure

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Biological Activity

3-Deoxysappanchalcone is a naturally-occurring chalcone compound isolated from Caesalpinia sappan L. (Leguminosae), which possesses anti-allergic, antiviral, anti-inflammatory and antioxidant activities. 3-Deoxysappanchalcone exerts anti-inflammatory activity via induce heme oxygenase-1 (HO-1) expression by activating the AKT/mTOR pathway in murine macrophages. 3-Deoxysappanchalcone also exhibits anti-influenza virus activity (H3N2, IC50 = 1.06 μM).

Chemical Information
Molecular Weight 270.28
Formula C16H14O4
CAS Number 112408-67-0
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic)
Storage 4°C, protect from light
References

[1] Jin-Young Lee, et al. Biomol Ther (Seoul). 3-Deoxysappanchalcone Inhibits Cell Growth of Gefitinib-Resistant Lung Cancer Cells by Simultaneous Targeting of EGFR and MET Kinases

[2] Dian Lv, et al. Heliyon. 3-Deoxysappanchalcone isolated from Caesalpinia sinensis shows anticancer effects on HeLa and PC3 cell lines: invasion, migration, cell cycle arrest, and signaling pathway

[3] Ah-Won Kwak, et al. Phytomedicine. The 3-deoxysappanchalcone induces ROS-mediated apoptosis and cell cycle arrest via JNK/p38 MAPKs signaling pathway in human esophageal cancer cells

[4] Xiaorong Fu, et al. Front Cell Dev Biol. 3-Deoxysappanchalcone Inhibits Skin Cancer Proliferation by Regulating T-Lymphokine-Activated Killer Cell-Originated Protein Kinase in vitro and in vivo

[5] Young Eun Kim, et al. Biomol Ther (Seoul). 3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling

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Keywords: 3-Deoxysappanchalcone  supplier, Anti-infection, inhibitors, activators

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