Free shipping on all orders over $ 500

Protosappanin A

Cat. No. M10696
Protosappanin A Structure
Synonym:

原苏木素A; PTA

Size Price Availability Quantity
1mg USD 185  USD185 In stock
5mg USD 540  USD540 In stock
10mg USD 860  USD860 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Protosappanin A (PTA), an immune agent, is a major biphenyl compound isolated from Caesalpinia sappan L that inhibits the JAK2/STAT3-dependent inflammatory pathway by down-regulating the phosphorylation of JAK2 and STAT3.

Chemical Information
Molecular Weight 272.25
Formula C15H12O5
CAS Number 102036-28-2
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage 4°C protect from light dry
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Li-Xi Liao, et al. ACS Chem Neurosci. Protosappanin A Maintains Neuronal Mitochondrial Homeostasis through Promoting Autophagic Degradation of Bax

[2] Qiang Huang, et al. Int J Clin Exp Pathol. Protosappanin a inhibits osteoclastogenesis via reducing oxidative stress in RAW264.7 cells

[3] Jian Wu, et al. Pharmacol Res. Protosappanin A protects against experimental autoimmune myocarditis, and induces metabolically reprogrammed tolerogenic DCs

[4] Li-Chao Wang, et al. Chin J Nat Med. Protosappanin A exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia

[5] Jian Wu, et al. Naunyn Schmiedebergs Arch Pharmacol. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway

Related JAK Products
Londamocitinib

Londamocitinib is a potent and selective JAK1 inhibitor with anti-inflammatory activity.

SJ1008030 TFA

SJ1008030 TFA is a JAK2 PROTAC which selectively degrades JAK2.

DPP

DPP is a Platinum(IV) complex, bearing pterostilbene-derived axial ligand.

STAT3-IN-18

STAT3-IN-18 is a platinum (IV) complex with an axial ligand derived from sandalwood.

JAK-IN-28

JAK-IN-28 is a JAK inhibitor.

  Catalog
Abmole Inhibitor Catalog




Keywords: Protosappanin A, 原苏木素A; PTA supplier, JAK, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.