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Protosappanin A

Cat. No. M10696
Protosappanin A Structure

原苏木素A; PTA

Size Price Availability Quantity
1mg USD 185  USD185 In stock
5mg USD 540  USD540 In stock
10mg USD 860  USD860 In stock
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Quality Control & Documentation
Biological Activity

Protosappanin A (PTA), an immune agent, is a major biphenyl compound isolated from Caesalpinia sappan L that inhibits the JAK2/STAT3-dependent inflammatory pathway by down-regulating the phosphorylation of JAK2 and STAT3.

Chemical Information
Molecular Weight 272.25
Formula C15H12O5
CAS Number 102036-28-2
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage 4°C protect from light dry
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Li-Xi Liao, et al. ACS Chem Neurosci. Protosappanin A Maintains Neuronal Mitochondrial Homeostasis through Promoting Autophagic Degradation of Bax

[2] Qiang Huang, et al. Int J Clin Exp Pathol. Protosappanin a inhibits osteoclastogenesis via reducing oxidative stress in RAW264.7 cells

[3] Jian Wu, et al. Pharmacol Res. Protosappanin A protects against experimental autoimmune myocarditis, and induces metabolically reprogrammed tolerogenic DCs

[4] Li-Chao Wang, et al. Chin J Nat Med. Protosappanin A exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia

[5] Jian Wu, et al. Naunyn Schmiedebergs Arch Pharmacol. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway

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Keywords: Protosappanin A, 原苏木素A; PTA supplier, JAK, inhibitors, activators

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