About 30 results found for searched term "RET" (0.012 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1758 | Foretinib | c-Met |
| GSK089; EXEL-2880; XL880; GSK1363089 | ||
| Foretinib (XL880, GSK1363089) is a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2 (VEGFR2) with IC50 value of 0.4 nM for c-MET. | ||
| M1961 | Acitretin (Ro 10-1670) | RAR/RXR |
| Etretin; Ro 10-1670 | ||
| Acitretin (Ro 10-1670) is a second-generation retinoid. | ||
| M2163 | Pretomanid | Anti-infection |
| PA-824; (S)-PA 824 | ||
| Pretomanid (PA-824) is a novel, orally active nitroimidazole derivative with antimycobacterial activity for use in tuberculosis-related studies. | ||
| M2242 | Altretamine | DNA Alkylator/Crosslinker |
| Hexalen | ||
| Altretamine is an antitumor agent which also acts as a chemosterilant for male houseflies and other insects. | ||
| M2274 | Fosbretabulin disodium | Microtubule |
| Combretastatin A-4 phosphate, CA4P | ||
| Fosbretabulin disodium (Combretastatin A-4 phosphate) is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM. | ||
| M2777 | IPI-504 hydrochloride | HSP |
| Retaspimycin hydrochloride; IPI-504 hcl | ||
| IPI-504 (Retaspimycin) hydrochloride is a potent inhibitor of HSP90 with EC50 of 63 nM. | ||
| M2832 | Mechlorethamine hydrochloride | Others |
| Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crosslinking two strands and preventing cell duplication. | ||
| M2887 | Norethindrone | Progesterone Receptor |
| Norethisterone | ||
| Norethindrone is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone. | ||
| M2974 | Retapamulin | Antibiotic |
| SB-275833 | ||
| Retapamulin (SB-275833) is a topical antibiotic, which binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM. | ||
| M3150 | Fenretinide | RAR/RXR |
| 4-HPR | ||
| Fenretinide (4-HPR) is a synthetic retinoid deriverative. Fenretinide is shown to exhibit binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death. | ||
| M3683 | Retaspimycin | HSP |
| IPI-504 | ||
| Retaspimycin is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90). | ||
| M3901 | Combretastatin A4 | Microtubule |
| CRC 87-09, NSC 817373, CA-4 | ||
| Combretastatin A4 (CA-4), which is a natural stilbene isolated from Combretum caffrum, is a microtubule-destabilizing agent that binds to the colchicine domain on β-tubulin and exhibits a lower toxicity profile than paclitaxel or the Vinca alkaloids. | ||
| M3902 | Quercetin (>99%) | Senolytics |
| Meletin, Sophoretin | ||
| Quercetin is a PI3K inhibitor with IC50 of 2.4-5.4 μM that has been shown to cause potent reversible inhibition of fatty-acid synthase. | ||
| M1556 | Hesperetin | p38 MAPK |
| Hesperitin | ||
| Hesperetin is a potent and broad-spectrum inhibitor against human UGT activity. | ||
| M4553 | Tangeretin | Notch |
| Tangeritin; NSC53909; NSC618905; Ponkanetin | ||
| Tangeretin is a flavonoid from citrus fruit peels, and is also selected as a Notch-1 inhibitor, which plays an important role in anti-inflammatory responses and neuroprotective effects in several disease models. | ||
| M4571 | Neohesperidin | Others |
| Hesperetin 7-O-neohesperidoside | ||
| Neohesperidin is an antioxidant agent with an IC50 of 22.31 μg/ml in the 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay. | ||
| M4607 | Phloretin | SGLT |
| NSC 407292; RJC 02792 | ||
| Phloretin (NSC 407292; RJC 02792) is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). | ||
| M5299 | Olumacostat glasaretil | Acetyl-CoA Carboxylase |
| Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). | ||
| M5482 | CB1954 | Others |
| Tretazicar | ||
| CB1954(Tretazicar) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2. | ||
| M5636 | Etretinate | Apoptosis |
| Tegison, Ethyl etrinoate, Retinoid, Etretinato | ||
| Etretinate is an orally available aromatic retinoid that has been shown to be effective in studies of cow skin and other skin syndromes. It can activate retinoid receptor, induce cell differentiation, inhibit cell proliferation and inhibit tissue infiltration. | ||
| M5689 | Hesperidin | Apoptosis |
| Hesperetin 7-rutinoside | ||
| Hesperidin (HP) is a bioflavonoid that plays a role in plant defense and is abundant in citrus species, such as grapefruit, lemon and orange. Hesperidin is used effectively as a supplemental agent in complementary therapy protocols. | ||
| M5715 | Isotretinoin | Others |
| 13-cis-Retinoic acid | ||
| Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne. It was first developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M5806 | Nandrolone decanoate | Androgen Receptor |
| Deca Durabolin, 19-Nortestosterone decanoate, Retabolil | ||
| Nandrolone Decanoate is a mild form of an anabolic steroid. | ||
| M5927 | Retinoic acid | PPAR |
| ATRA; Tretinoin; Vitamin A acid; all-trans-Retinoic acid | ||
| Retinoic acid is A metabolite of vitamin A and plays an important role in cell growth, differentiation and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors with an IC50 of 14 nM for RARα/β/γ. The Kd value of Retinoic acid combined with PPARβ/δ is 17 nM. Retinoic acid inhibits the transcription factor Nrf2 by activating Retinoic acid receptors. | ||
| M6530 | Bretazenil | Others |
| Bretazenil is a benzodiazepine partial agonist. | ||
| M7523 | Potassium acetate | Metabolite/Endogenous Metabolite |
| Diuretic salt, Potassium ethanoate | ||
| Potassium acetate is the potassium salt of acetic acid, which is a synthetic carboxylic acid with antibacterial and antifungal properties. | ||
| M7964 | Nordihydroguaiaretic acid | Lipoxygenase |
| NDGA | ||
| Nordihydroguaiaretic acid (NDGA) is a 5-lipoxygenase (5LOX) (IC50=8 μM) and tyrosine kinase inhibitor. | ||
| M8438 | Retro-2 cycl | Anti-infection |
| RN 1-001 | ||
| Retro-2 cycl is a non-toxic inhibitor of the endosome-to-Golgi retrograde transport that selectively protect cells from ricin, cholera toxin, and Shiga-like toxins, without affecting compartment morphology, endogenous retrograde cargos, or other trafficking steps. | ||
| M9137 | Elamipretide TFA | Peptides |
| MTP-131; Bendavia; RX-31; SS-31 | ||
| Elamipretide TFA, also known as MTP-131, is a cardiolipin peroxidase inhibitor and mitochondria-targeted peptide. | ||
| M9219 | all-trans 4-Keto Retinoic Acid | Vitamin |
| all-trans-4-Oxoretinoic acid | ||
| all-trans 4-Keto Retinoic Acid is an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs). | ||
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