All AbMole products are for research use only, cannot be used for human consumption.
Quercetin significantly down regulates myofibroblast differentiation and fibrotic markers, such as α-smooth muscle actin (α-SMA) and Collagen III (Col III), in both HCFs and HKCs. Collagen III secretion was reduced 80% in both HCFs and HKCs following Quercetin treatment.Furthermore, Quercetin reduced lactate production by HKCs to normal HCF levels. Quercetin down regulated TGF-βR2 and TGF-β2 expression in HKCs suggesting a significant link to the TGF-β pathway. Quercetin is a key regulator of fibrotic markers and ECM assembly by modulating cellular metabolism and TGF-β signaling. Quercetin strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. Quercetin or the combined use of adenosine diphosphate and thromboxane A(2) inhibitors abrogated platelet spreading on these surfaces to a similar extent. The inhibitory effect of quercetin on platelet kinases blocks early signaling events preventing a complete platelet spreading. PKC inhibitors H-7 and quercetin protect BPAEC from TNF induced injuries and PKC play an important role in EC activation by TNF.
Nat Commun. 2023 Nov 27;14(1):7783.
Local H2 release remodels senescence microenvironment for improved repair of injured bone
Quercetin (>99%) purchased from AbMole
Front Microbiol. 2023 Mar 2;14:1120048.
Specific TLR-mediated HSP70 activation plays a potential role in host defense against the intestinal parasite Giardia duodenalis
Quercetin (>99%) purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Mice bearing LNCaP xenografts or PC-3 xenografts |
| Formulation | 25% hydroxypropyl-β-cyclodextrin |
| Dosages | 75mg/kg |
| Administration | |
| Molecular Weight | 302.24 |
| Formula | C15H10O7 |
| CAS Number | 117-39-5 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Senolytics Products |
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| Terreic acid
Terreic acid is a quinone epoxide antibiotic and a potent Btk inhibitor, blocking the interaction between PKC and the PH domain of Btk.T Terreic acid also acts on HMC-1 human mast cell lysates, inhibiting the binding of GST-BtkPH to PKC with an IC50 of approximately 100 μM. Terreic acid also acts on HMC-1 human mast cell lysates to inhibit the binding of GST-BtkPH to PKC, with an IC50 of approximately 100 μM. In addition, Terreic acid simultaneously reduces the percentage of senescent cells and SASP expression in cells exposed to stress stimuli. |
| FOXO4-DRI acetate
FOXO4-DRI acetate is a cell-permeable peptide antagonist that blocks the interaction between FOXO4 and p53.FOXO4-DRI is an anti-aging peptide that induces apoptosis in senescent cells. |
| β-Galactosidase
β-Galactosidase is a glycoside hydrolase that hydrolyzes the β-glycosidic bond formed between galactose and its organic part. In Escherichia coli, the lacZ gene is the structural gene for β-galactosidase and can be used as part of the lac manipulator of the inducible system. β-Galactosidase hydrolyzes lactose to form glucose and galactose, which enter glycolysis, and also catalyzes the transgalactosylation of lactose to isolactose, which can be cleaved to monosaccharides. |
| Quercetin
Quercetin is a PI3K inhibitor with IC50 of 2.4-5.4 μM that has been shown to cause potent reversible inhibition of fatty-acid synthase. |
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Products are for research use only. Not for human use. We do not sell to patients.
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