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Quercetin

Cat. No. M11068
Quercetin Structure
Synonym:

Meletin, Sophoretin

Size Price Availability Quantity
5g USD 50  USD50 In stock
10g USD 70  USD70 In stock
20g USD 110  USD110 In stock
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Quality Control & Documentation
Biological Activity

Quercetin significantly down regulates myofibroblast differentiation and fibrotic markers, such as α-smooth muscle actin (α-SMA) and Collagen III (Col III), in both HCFs and HKCs. Collagen III secretion was reduced 80% in both HCFs and HKCs following Quercetin treatment.Furthermore, Quercetin reduced lactate production by HKCs to normal HCF levels. Quercetin down regulated TGF-βR2 and TGF-β2 expression in HKCs suggesting a significant link to the TGF-β pathway. Quercetin is a key regulator of fibrotic markers and ECM assembly by modulating cellular metabolism and TGF-β signaling. Quercetin strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. Quercetin or the combined use of adenosine diphosphate and thromboxane A(2) inhibitors abrogated platelet spreading on these surfaces to a similar extent. The inhibitory effect of quercetin on platelet kinases blocks early signaling events preventing a complete platelet spreading. PKC inhibitors H-7 and quercetin protect BPAEC from TNF induced injuries and PKC play an important role in EC activation by TNF.

Product Citations
Chemical Information
Molecular Weight 302.24
Formula C15H10O7
CAS Number 117-39-5
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Priyanka Singh, et al. Plant Physiol Biochem. The role of quercetin in plants

[2] Marjorie Reyes-Farias, et al. Int J Mol Sci. The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism

[3] Susanne Andres, et al. Mol Nutr Food Res. Safety Aspects of the Use of Quercetin as a Dietary Supplement

[4] Yoshinori Marunaka, et al. Molecules. Actions of Quercetin, a Polyphenol, on Blood Pressure

[5] Hoda M Eid, et al. Curr Med Chem. The Antidiabetic Potential of Quercetin: Underlying Mechanisms

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Keywords: Quercetin, Meletin, Sophoretin supplier, Senolytics, inhibitors, activators


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