Terreic acid is a quinone epoxide antibiotic and a potent Btk inhibitor, blocking the interaction between PKC and the PH domain of Btk.T Terreic acid also acts on HMC-1 human mast cell lysates, inhibiting the binding of GST-BtkPH to PKC with an IC50 of approximately 100 μM. Terreic acid also acts on HMC-1 human mast cell lysates to inhibit the binding of GST-BtkPH to PKC, with an IC50 of approximately 100 μM. In addition, Terreic acid simultaneously reduces the percentage of senescent cells and SASP expression in cells exposed to stress stimuli.
| Molecular Weight | 154.12 |
| Formula | C7H6O4 |
| CAS Number | 121-40-4 |
| Form | Solid |
| Storage | -20°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Senolytics Products |
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| FOXO4-DRI acetate
FOXO4-DRI acetate is a cell-permeable peptide antagonist that blocks the interaction between FOXO4 and p53.FOXO4-DRI is an anti-aging peptide that induces apoptosis in senescent cells. |
| β-Galactosidase
β-Galactosidase is a glycoside hydrolase that hydrolyzes the β-glycosidic bond formed between galactose and its organic part. In Escherichia coli, the lacZ gene is the structural gene for β-galactosidase and can be used as part of the lac manipulator of the inducible system. β-Galactosidase hydrolyzes lactose to form glucose and galactose, which enter glycolysis, and also catalyzes the transgalactosylation of lactose to isolactose, which can be cleaved to monosaccharides. |
| Quercetin
Quercetin is a PI3K inhibitor with IC50 of 2.4-5.4 μM that has been shown to cause potent reversible inhibition of fatty-acid synthase. |
| Quercetin (>99%)
Quercetin is a PI3K inhibitor with IC50 of 2.4-5.4 μM that has been shown to cause potent reversible inhibition of fatty-acid synthase. |
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