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Cat. No. M2887
Norethindrone Structure


Size Price Availability Quantity
100mg USD 55  USD55 In stock
500mg USD 88  USD88 In stock
1g USD 135  USD135 In stock
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Quality Control & Documentation
Biological Activity

Norethindrone is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone.

Customer Product Validations & Biological Datas
Source J Clin Pharmacol (2012). Figure 1. Norethindrone
Method PK and Pharmacodynamic (PD) Assessments
Cell Lines
Concentrations 0.5 mg/kg
Incubation Time 1, 7, 14, 21, 22, 28, 35, 42, 49, 50, and 56 days
Results Mean steady-state Cmax, AUC, and Cmin and their 90% CIs of their GLSMRs fell within the no-effect limit boundary of 0.80 to 1.25.
Protocol (for reference only)
Cell Experiment
Cell lines Human epithelial cervical cancer cells
Preparation method Thereafter, the cells were incubated with serum-free, phenol-free DMEM for 2 hrs, before treatment with 100 nM DEX, MPA, P4 and NET-A for 1 hr. Cells were crosslinked for 10 min at 37°C with1% formaldehyde and the reaction was stopped with 0.1 mM glycine for 5 min, shaking at room temperature.
Concentrations 100 nM
Incubation time 1 h
Animal Experiment
Animal models Female Sprague-Dawley rats
Formulation corn oil
Dosages 3 μg/rat/day
Administration oral
Chemical Information
Molecular Weight 298.42
Formula C20H26O2
CAS Number 68-22-4
Form Solid
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Africander DJ, et al. J Steroid Biochem Mol Biol. A comparative study of the androgenic properties of progesterone and the progestins, medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A).

[2] Govender Y, et al. PLoS One. The injectable-only contraceptive medroxyprogesterone acetate, unlike norethisterone acetate and progesterone, regulates inflammatory genes in endocervical cells via the glucocorticoid receptor.

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Keywords: Norethindrone, Norethisterone supplier, Progesterone Receptor, inhibitors, activators

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