About 30 results found for searched term "RA-2" (0.005 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1733 | TG101348 | JAK |
| Fedratinib; SAR302503 | ||
| TG101348 is a selective small-molecule Janus kinase 2 (JAK2) inhibitor with IC50 of 3 nM. | ||
| M1761 | Vemurafenib (PLX4032) | Raf |
| RG7204; RO5185426 | ||
| Vemurafenib (PLX4032) is a first-in-class, potent, selective inhibitor of B-Raf that inhibits RAFV600E and C-RAF-1 activity with IC50s of 31 nM and 48 nM, respectively.In addition, Vemurafenib induces autophagy. | ||
| M1768 | Rapamycin | mTOR |
| Sirolimus; Rapamune; AY-22989 | ||
| Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling. | ||
| M1802 | Lapatinib ditosylate monohydrate | EGFR/HER2 |
| GW572016 ditosylate monohydrate; GW2016 | ||
| Lapatinib (GW572016) ditosylate monohydrate is a selective and effective inhibitor of EGFR kinase (Ki = 3 nM), ErbB-2 kinase (Ki = 13 nM) and ErbB-4 kinase (Ki = 347 nM). | ||
| M1813 | PCI-24781 | HDAC |
| Abexinostat; CRA-024781 | ||
| PCI-24781 is a novel and potent histone deacetylase (HDAC) inhibitor with IC50 value of 0.43 to 2.7 μM. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M1825 | PCI-32765 | BTK |
| Ibrutinib; CRA-032765 | ||
| PCI-32765 (Ibrutinib) is a potent, selective and orally bioavailable irreversible inhibitor of BTK with IC50 value of 0.46 nM. | ||
| M1863 | RAF265 | Raf |
| CHIR-265 | ||
| RAF265 is a novel, orally bioavailable dual inhibitor of RAF kinase and VEGFR2. | ||
| M1879 | XL147 | PI3K |
| Pilaralisib; SAR245408 | ||
| XL147 (SAR245408) is an orally bioavailable, selective small molecule Class I PI3K kinase family inhibitor. | ||
| M2021 | AG 18 | EGFR/HER2 |
| RG-50810；Tyrphostin 23；tyrA23；Tyrphostin A23 | ||
| AG-18 (Tyrphostin A23, tyrA23) inhibits EGFR with an IC50 of 35 μM. TyrA23 is also an inhibitor of CME and inhibits transferrin receptor internalization. | ||
| M2028 | Fludarabine | STAT |
| Fludara; NSC 118218; Fludarabinum; F-ara-A | ||
| Fludarabine (NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. Fludarabine markedly inhibited VSMC proliferation in cell culture. Fludarabine also induces significant reduction of STAT-1 phosphorylation, whereas it does not change JAK2 activation. Fludarabine exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. | ||
| M2155 | (1S-cis)-Milnacipran Hydrochloride | 5-HT Receptor |
| Levomilnacipran hydrochloride; F-2695 hydrochloride | ||
| (1S-cis)-Milnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia. | ||
| M2215 | Niraparib (MK-4827) | PARP |
| MK-4827 | ||
| MK-4827 (Niraparib) is a selective PARP1/2 inhibitor with an IC50 value of 3.8 nM/2.1 nM that increases the formation of PARP-DNA complexes through inhibition of PARPase activity, leading to DNA damage, apoptosis, PARP-1-dependent cell death (parthanatos) and cell death. Strong effector activity when acting on cancer cells harboring mutant BRCA-1 and BRCA-2. It is more than 330-fold more selective than PARP3, V-PARP and Tank1. | ||
| M2240 | Acarbose | Glucosidase |
| Prandase, Precose, BAY g 5421 | ||
| Acarbose (BAY G 5421) is an alpha-glucosidase inhibitor with oral activity (IC50=11 nM). Acarbose can enhance the hypoglycemic effect of sulfonylurea inhibitors or insulin. | ||
| M2278 | Bosentan Hydrate | Endothelin Receptor |
| Benzenesulfonamide Hydrate; Ro-47-0203 Hydrate | ||
| Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. | ||
| M2324 | Rabusertib (LY2603618) | Checkpoint |
| Rabusertib ; IC-83 | ||
| Rabusertib (LY2603618) is an effective and selective Chk1 inhibitor with an IC50 of 7 nM. | ||
| M2329 | Zoledronic acid | PKC |
| Zometa; Zomera; Zoledronate; CGP 42446; CGP42446A; ZOL 446 | ||
| Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects. | ||
| M2468 | Brimonidine Tartrate | Adrenergic Receptor |
| Brimonidine tartrate; AGN190342 tartrate; UK14304 tartrate | ||
| Brimonidine Tartrate is a highly selective α-adrenergic receptor antagonist with an EC50 of 0.45 nM for α2A adrenoreceptor, and has been used to study open-angle glaucoma or ocular hypertension. | ||
| M2995 | Salinosporamide A | Proteasome |
| (-)-Salinosporamide A; ML 858; NPI 0052; Marizomib | ||
| Salinosporamide A (NPI-0052, Marizomib) is a novel marine derived proteasome inhibitor which inhibits CT-L, C-L, and T-L proteasome activities in human erythrocyte-derived 20S proteasomes with EC50 of 3.5 nM, 430 nM, 28 nM. | ||
| M3222 | Peramivir Trihydrate | Anti-infection |
| BCX-1812 Trihydrate; RWJ-270201 Trihydrate; S-021812 Trihydrate | ||
| Peramivir Trihydrate is a trihydrate of the anti-infection agent peramivir (RWJ-270201,BCX-1812) which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM. | ||
| M3278 | MK-5172 (Grazoprevir) | HCV Protease |
| Grazoprevir; MK5172 | ||
| MK-5172 is a novel NS3/4, a protease inhibitor for chronic HCV infection (Enzyme Ki for genotype1b, 2a, 2b and 3a at ＜0.02, 0.15, 0.02 and 0.7 nM, respectively). | ||
| M3586 | Pramipexole dihydrochloride Monohydrate | Dopamine Receptor |
| Pramipexole 2HCL monohydrate | ||
| Pramipexole dihydrochloride Monohydrate is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM. | ||
| M3663 | K-Ras(G12C) inhibitor 9 | Ras |
| K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C). | ||
| M3699 | Letrozole | Animal Modeling |
| Femara; CGS 20267 | ||
| Letrozole is an orally active, potent, selective, nonsteroidal, third-generation aromatase (CYP19A1) inhibitor, a synthetic benzyltriazole derivative, which is used in the construction of animal models of polycystic ovary syndrome (PCOS), as well as in studies related to postoperative hormone-responsive breast cancer. | ||
| M11542 | Ochromycinone | STAT |
| (Rac)-STA-21；STA 21 | ||
| Ochromycinone ((RAC-STA-21) is a natural antibiotic and a selective inhibitor of STAT3. Ochromycinone can inhibit STAT3 DNA binding activity and STAT3 dimerization. Ochromycinone has anticancer and antibacterial activities. | ||
| M3768 | Ixabepilone | Microtubule |
| Ixempra, BMS-247550, NSC 710428 | ||
| Ixabepilone (BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors. | ||
| M1621 | Ustekinumab | IL Receptor/Related |
| Anti-IL-12/IL-23,Stelara, CNTO 1275 | ||
| Ustekinumab is a human monoclonal antibody that targets IL12 and IL23, natural proteins that regulate the immune system and immune-mediated inflammatory diseases. | ||
| M4424 | Tetramethylpyrazine (2,3,5,6-Tetramethylpyrazine) | Apoptosis |
| Chuanxiongzine; Tetramethylpyrazine；Ligustrazine | ||
| Tetramethylpyrazine (2,3,5,6-Tetramethylpyrazine) is an alkyl pyrazine extracted from Ligusticum wallichii (Chuan Xiong), often used as a flavor in French fries, bread, tea, dairy products, bean products and other food. Ligustrazine has potential antineural and anti-inflammatory activities in rats. | ||
| M4444 | 2,3,5,4-tetrahydroxyl-diphenylethylene-2-o-glucoside | Others |
| 2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside | ||
| 2,3,4', 5-Tetrahydroxystilbene 2-O-D-glucoside was isolated from the roots of polygonum species and inhibited the formation of 5-Hete, HHT and Thromboxane B2. | ||
| M4550 | Maslinic-acid | NF-κB |
| Crategolic acid; 2α-Hydroxyoleanolic acid | ||
| Maslinic-acid (MA) is a natural triterpenoid with a wide range of biological activities, such as anti-tumor, anti-diabetes, antioxidant, heart-protective, neuroprotective, anti-parasitic and growth stimulating, Maslinic acid inhibited THE DNA binding activity of NF-κB P65 and eliminated the PHOSPHORylation of IκB-α. | ||
| M4611 | oleanolic acid-3-O-β-D-glucopyranosyl (1→2)-α-L-arabinopyranoside | Others |
| Oleanolic | ||
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