About 26 results found for searched term "PiB" (0.054 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1741 | Ganetespib | HSP |
| STA-9090 | ||
| Ganetespib (STA-9090) is a potent synthetic small molecule inhibitor of Hsp90 with potential antineoplastic activity. | ||
| M1762 | Luminespib (AUY922) | HSP |
| NVP-AUY922; Luminespib | ||
| Luminespib (AUY922) is a small molecule Heat Shock Protein 90 (HSP90) inhibitor with IC50 values of 13 and 21 nM for HSP90α and HSP90β respectively. | ||
| M1829 | Torcetrapib | CETP |
| CP-529414 | ||
| Torcetrapib (CP-529414) is a prototype cholesteryl ester transfer protein (CETP) inhibitor with potential for decreasing atherosclerotic disease, increased cardiovascular events in clinical trials. | ||
| M1949 | Onalespib (AT13387) | HSP |
| AT-13387; Onalespib | ||
| Onalespib (AT13387) is a novel, high-affinity heat-shock protein 90 (HSP90) inhibitor with IC50 of 18 nM in A375 cells. | ||
| M2142 | Anacetrapib | CETP |
| MK-0859 | ||
| Anacetrapib is an orally active and potent inhibitor of CETP with IC50 of 7.9 nM and 11.8 nM for rhCETP and mutant CETP(C13S) respectively. | ||
| M2330 | Evacetrapib | CETP |
| LY2484595 | ||
| Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP which inhibited human recombinant CETP protein (5.5 nM IC(50)) and CETP activity in human plasma (36 nM IC(50)) in vitro. | ||
| M3438 | Dalcetrapib | CETP |
| JTT-705, RO4607381 | ||
| Dalcetrapib (JTT-705) is a rhCETP inhibitor with IC50 of 0.2 μM that increases the plasma HDL cholesterol. | ||
| M4402 | Epiberberine | AChR/AChE |
| Epiberberine is a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine is also a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean). | ||
| M7649 | PiB | Others |
| PiB is an inhibitor of the peptidylprolyl isomerase Pin-1. | ||
| M8599 | Epiblastin A | Others |
| Epiblastin A is triamterene derivative that potently induces reprograming of epiblast stem cells (EpiSC) into embryonic stem cells (ESC). | ||
| M13504 | Epibrassinolide | Plant growth regulators |
| 24-Epibrassinolide; B1105; BP55 | ||
| Epibrassinolide (24-Epibrassinolide) is a ubiquitously occurring plant growth hormone which shows great potential to alleviate heavy metals and pesticide stress in plants. | ||
| M14547 | Epiberberine chloride | AChR/AChE |
| Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. | ||
| M16919 | 2-Epi-3a-epiburchellin | Lignans |
| 2-Epi-3a-epiburchellin | ||
| M18421 | 3-Epibetulinic acid | Others |
| 3-Epibetulinic acid | ||
| M18686 | Oxyepiberberine | Others |
| Oxyepiberberine | ||
| M20676 | Pimitespib | HSP |
| TAS-116 | ||
| TAS-116 is a novel, small-molecule HSP90 inhibitor which inhibits geldanamycin-FITC binding to HSP90 proteins with Ki values of 34.7 nmol/L, 21.3 nmol/L, >50,000 nmol/L, and >50,000 nmol/L for HSP90α, HSP90β, GRP94, and TRAP1, respectively. Furthermore, TAS-116 does not inhibit other ATPases such as HSP70 (IC50 >200 μmol/L). | ||
| M20732 | Pibrentasvir (ABT-530) | HCV Protease |
| Pibrentasvir (ABT-530) is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with EC50 ranging from 1.4 pM to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6. | ||
| M21042 | DCPIB | Potassium Channel |
| DCPIB is a specific and potent inhibitor of volume-regulated anion channels (VRAC). DCPIB potently inhibits several K2P channels with no voltage dependence, including TRESK, TASK1, and TASK3. DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM. | ||
| M27592 | Icapamespib | HSP |
| PU-HZ151 | ||
| Icapamespib (PU-HZ151) is a potent HSP90 inhibitor with an EC50 of 5 nM. Icapamespib is able to cross blood-brain barrier. | ||
| M27649 | Onalespib lactate | HSP |
| Onalespib lactate is a potent and cross the blood-brain barrier heat-shock-protein-90 (Hsp90) inhibitor with an Kd value of 0.71 nM. Onalespib lactate inhibits the proliferation, survival and migration. Onalespib lactate decreases the expression of EGFR, p-EGFR, AKT, P-AKT, ERK1/2, P-ERK1/2, S6, P-S6 protein. Onalespib lactate shows antitumor activity. Onalespib lactate has the potential for the research of non-small cell lung cancer (NSCLC). | ||
| M28853 | Piboserod hydrochloride | 5-HT Receptor |
| SB-207266 hydrochloride | ||
| Piboserod (SB 207266) Hcl is a selective 5-HT(4) receptor antagonist. | ||
| M40942 | Obicetrapib | CETP |
| DEZ-001; TA-8995 | ||
| Obicetrapib (DEZ-001) is a selective, orally active cholesterol transporter protein (CETP) inhibitor that blocks the function of CETP and significantly reduces LDL-C while significantly increasing HDL-C levels, and may be used in studies related to atherosclerosis and Alzheimer's disease (AD). | ||
| M42212 | Epiboxidine hydrochloride | AChR/AChE |
| Epiboxidine hydrochloride is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. | ||
| M45023 | Tetrahydroepiberberine | Antifungal |
| Tetrahydroepiberberine is a isoquinoline alkaloid isolated from Corydalis impatiens (Pall). Tetrahydroepiberberine has antifungal and selective inhibition against the PI-3 virus activities. | ||
| M57268 | (±)-Epibatidine dihydrochloride | Others |
| (±)-Epibatidine (CMI 545) dihydrochloride is an agonist of nicotinic with potent analgetic activity. | ||
| M56529 | (±)-Epibatidine | AChR/AChE |
| (±)-Epibatidine is a nicotinic agonist. | ||
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