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PiB

Cat. No. M7649

All AbMole products are for research use only, cannot be used for human consumption.

PiB Structure

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Quality Control & Documentation
Biological Activity

PiB is an inhibitor of the peptidylprolyl isomerase Pin-1. Inhibition of Pin-1 leads to destabilization of the transcription factor Nanog, which is required for maintenance of embryonic stem cell cultures.

Chemical Information
Molecular Weight 438.39
Formula C22H18N2O8
CAS Number 64005-90-9
Solubility (25°C) DMSO: 1-2 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Silvio R Meier, et al. 11 C-PiB and 124 I-Antibody PET Provide Differing Estimates of Brain Amyloid-β After Therapeutic Intervention

[2] Milos D Ikonomovic, et al. Post-mortem analyses of PiB and flutemetamol in diffuse and cored amyloid-β plaques in Alzheimer's disease

[3] Sara Rosengren, et al. Diagnostic Accuracy of [ 11 C]PIB Positron Emission Tomography for Detection of Cardiac Amyloidosis

[4] Tanja Kero, et al. Quantification of 11 C-PIB kinetics in cardiac amyloidosis

[5] Ryogo Minamimoto, et al. Significance of 11 C-PIB PET/CT in cardiac amyloidosis compared with 99m Tc-aprotinin scintigraphy: A pilot study

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Keywords: PiB supplier, inhibitors, activators

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