About 27 results found for searched term "MOR agonist-1" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41809 | D3R/MOR antagonist 1 | Dopamine Receptor |
| D3R/MOR antagonist 1 is a D3R/MOR antagonist (Ki: 46.5 nM and 691 nM respectively). | ||
| M41894 | MOR agonist-1 | Opioid Receptor |
| MOR agonist-1 is a MOR (μ-opioid receptor) agonist. | ||
| M1816 | Zibotentan | Endothelin Receptor |
| ZD4054 | ||
| Zibotentan (ZD4054) is a more selective and specific endothelin-A receptor (ETAR) antagonist with an IC50 value of 21 nM. | ||
| M3106 | UNC1215 | Epigenetic Reader Domain |
| UNC1215 is a potent and selective MBT (malignant brain tumor) antagonist, which binds L3MBTL3 with IC50 of 40 nM and Kd of 120 nM, 50-fold selective versus other members of the human MBT family. | ||
| M3261 | Almorexant | OX Receptor |
| ACT-078573 | ||
| Almorexant is a competitive OX1 and OX2 orexin receptor antagonist with IC50 of 13 and 8 nM, respectively. | ||
| M4552 | Nobiletin | Autophagy |
| Nobiletin is a citrus flavonoid with anti-inflammatory, anti-cancer, cholesterol lowering, memory protection activities. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes. | ||
| M10455 | BMP signaling agonist sb4 | TGF-beta/Smad |
| SB-4 | ||
| BMP signaling agonist sb4 (SB-4) is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM. BMP signaling agonist sb4 activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9. | ||
| M10721 | Dimemorfan phosphate | Sigma Receptor |
| Dimemorfan phosphate is a potent agonist of sigma 1 receptor that is effective in suppressing cough. | ||
| M10955 | Nemorexant | OX Receptor |
| ACT-541468 | ||
| Nemorexant (ACT-541468) is an effective orexin receptor antagonist. It also has IC50s of 2 nM and 3 nM for the Ox1 receptor and Ox2 receptor, respectively. | ||
| M14034 | Almorexant hydrochloride | OX Receptor |
| ACT-078573 hydrochloride | ||
| Almorexant hydrochloride (ACT 078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM, respectively. | ||
| M21317 | EST73502 | Opioid Receptor |
| EST73502 is a selective, orally active, μ-opioid receptor (μ-opioid receptor/MOR) agonist and σ1 receptor (σ1R) antagonist that crosses the blood-brain barrier with Ki values of 64 nM and 118 nM for MOR and σ1R effects, respectively. EST73502 can be used in pain relief studies. | ||
| M28208 | Naldemedine tosylate | Opioid Receptor |
| S-297995 tosylate | ||
| Naldemedine (S-297995) tosylate is an orally active μ-opioid receptor antagonist (PAMORA). Naldemedine tosylate shows potent binding affinities (Ki=0.34, 0.43, 0.94 nM, respectively) and antagonist activities (IC50=25.57, 7.09, 16.1 nM, respectively) for recombinant human μ-, δ-, and κ- opioid receptors. Naldemedine can be used in opioid-induced constipation (OIC) research. | ||
| M28311 | CaV1.3 antagonist-1 | Calcium Channel |
| CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research. | ||
| M28907 | Relamorelin acetate | Ghrelin Receptor/GHSR |
| RM-131 acetate; BIM-28131 acetate | ||
| Relamorelin (RM-131) acetate, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for GHS-1a receptor. Relamorelin acetate is centrally penetrant. Relamorelin acetate increases growth hormone levels and accelerates gastric emptying. Relamorelin acetate has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research. | ||
| M29841 | Relamorelin TFA | Ghrelin Receptor/GHSR |
| RM-131 TFA; BIM-28131 TFA | ||
| Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for GHS-1a receptor. Relamorelin TFA is centrally penetrant. Relamorelin TFA increases growth hormone levels and accelerates gastric emptying. Relamorelin TFA has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research. | ||
| M30443 | Relamorelin | Ghrelin Receptor/GHSR |
| RM-131; BIM-28131 | ||
| Relamorelin (RM-131), a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for GHS-1a receptor. Relamorelin is centrally penetrant. Relamorelin increases growth hormone levels and accelerates gastric emptying. Relamorelin has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research. | ||
| M30676 | Ulimorelin | Ghrelin Receptor/GHSR |
| TZP-101 | ||
| Ulimorelin (TZP-101) is a ghrelin receptor (GRLN) agonist with an EC50 of 29 nM and a Ki of 16 nM. Ulimorelin is a prokinetic agent and causes vasorelaxation through competitive antagonist action at α1-adrenoceptors. Ulimorelin stimulates intestinal motility and is used for malnutrition. | ||
| M30898 | Naldemedine | Opioid Receptor |
| S-297995 | ||
| Naldemedine (S-297995) is an orally active μ-opioid receptor antagonist (PAMORA). Naldemedine shows potent binding affinities (Ki=0.34, 0.43, 0.94 nM, respectively) and antagonist activities (IC50=25.57, 7.09, 16.1 nM, respectively) for recombinant human μ-, δ-, and κ- opioid receptors. Naldemedine can be used in opioid-induced constipation (OIC) research. Naldemedine is predicted to bind to 3CLpro encoded by SARS-CoV2 genome. | ||
| M38943 | Caulophyllogenin | PPAR |
| Caulophyllogenin is a triterpene saponin extracted from M. polimorpha. Caulophyllogenin is a partial PPARγ agonist, with an EC50 of 12.6 μM. Caulophyllogenin can be used for the research of type-2 diabetes, obesity, metabolic syndrome and inflammation. | ||
| M40652 | Adenosine receptor antagonist 2 | Adenosine Receptor |
| Adenosine receptor antagonist 2 is a potent, orally active and antitumor active adenosine receptor A2a/A2b antagonist with IC50 values of 1 nM and 3 nM, respectively. | ||
| M41810 | D3R/MOR antagonist 2 | Dopamine Receptor |
| D3R/MOR antagonist 2 is a D3R/MOR antagonist (Ki: 361 nM and 85.2 nM respectively). | ||
| M53886 | Endomorphin 1 | Opioid Receptor |
| Endomorphin 1, a high affinity, highly selective agonist of the μ-opioid receptor (Ki: 1.11 nM), displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM. | ||
| M53887 | Endomorphin 1 acetate | Opioid Receptor |
| Endomorphin 1 acetate, a high affinity, highly selective agonist of the μ-opioid receptor (Ki: 1.11 nM), displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM. | ||
| M56480 | SCH 50911 | GABA Receptor |
| SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. | ||
| M56473 | SCH 50911 hydrochloride | GABA Receptor |
| SCH 50911 hydrochloride, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. | ||
| M56021 | Amorfrutin B | PPAR |
| Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with Ki values of 19 nM and EC50 values of 73 nM, respectively. | ||
| M58386 | Moringin | TRP Channel |
| Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC50 of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. | ||
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