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UNC1215 is a potent and selective MBT (malignant brain tumor) antagonist, which binds L3MBTL3 with IC50 of 40 nM and Kd of 120 nM, 50-fold selective versus other members of the human MBT family.
| Cell Experiment | |
|---|---|
| Cell lines | HEK293T/17 cells |
| Preparation method | CellTiter-Glo luminescent cell viability assay |
| Concentrations | ~100 μM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 529.72 |
| Formula | C32H43N5O2 |
| CAS Number | 1415800-43-9 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Qianqian Wang, et al. PHF20L1 antagonizes SOX2 proteolysis triggered by the MLL1/WDR5 complexes
[3] Narkhyun Bae, et al. Developing Spindlin1 small-molecule inhibitors by using protein microarrays
[4] Brandi M Baughman, et al. The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer
[5] Lindsey I James, et al. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
| Related Epigenetic Reader Domain Products |
|---|
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dBRD9 dihydrochloride is a selective BRD9 PROTAC degrader. |
| BBC0403
BBC0403 is a selective BRD2 inhibitor with Kds of 7.64 μM and 41.37 μM for BRD2 (BD2) and BRD2 (BD1), respectively. |
| BAY-155
BAY-155 is a potent and selective menin-MLL tool inhibitor, with an IC50 of 8 nM. |
| FHT-1015
FHT-1015 is a potent SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor with IC50s of ≤10 nM. |
| ISOX-DUAL
ISOX-DUAL is a dual CBP/BRD4 inhibitor with IC50 values of 0.65 μM and 1.5 μM for CBP and BRD4, respectively. |
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