About 30 results found for searched term "ISO-1" (0.052 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3232 | Cortisone acetate | Animal Modeling |
| Cortisone 21-acetate | ||
| Cortisone acetate is the acetate form of Cortisone, a steroid hormone and glucocorticoid that suppresses the immune system, thereby reducing inflammatory pain and swelling at the site of injury.Cortisone acetate and epinephrine, the primary hormones released by the body in response to stress, elevate blood pressure. They can be used to construct animal models of hypertension. | ||
| M3971 | Isosteviol | ROS |
| Ketoisostevic Acid,NSC 231875 | ||
| Isosteviol is a tetracyclic diterpenoid obtained by acid hydrolysis of steviol glycoside extracts isolated from abundant Stevia rebaudiana plants. | ||
| M4240 | Shikonin | TNF Receptor |
| C.I. 75535; Isoarnebin 4; CAS# 54952-43-1 | ||
| Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844) is an effective and specific inhibitor of Pyruvate kinase M2 (PKM2). Shikonin is the main ingredient of Lithosia, a Chinese herb with a variety of biological activities. Shikonin acts as an anti-inflammatory by inhibiting tumor necrosis factor-α (TNF-α), Proteasome can inhibit the activation of nuclear factor-κB (NF-κB) signaling pathway. | ||
| M5533 | Corticosterone | GCR |
| 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B | ||
| Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system. Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. | ||
| M5695 | Hydrocortisone acetate | GCR |
| Hydrocortisone 21-acetate | ||
| Hydrocortisone acetate is a corticosteroid, used to decrease swelling, itching, and pain that is caused by minor skin irritations or by hemorrhoids. | ||
| M6804 | IBMX | PDE |
| IMX; Isobutylmethylxanthine; Methylisobutylxanthine; NSC165960; SC2964; 3-isobutyl-1-methylxanthine | ||
| IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. | ||
| M7426 | Travoprost | Prostaglandin Receptor |
| Fluprostenol isopropyl ester; AL6221; Flu-Ipr | ||
| Travoprost is a potent and selective FP prostaglandin receptor agonist. | ||
| M9082 | ISO-1 | NLR |
| MIF Antagonist; Macrophage Migration Inhibitory Factor | ||
| ISO-1, also known as MIF Antagonist, is a MIF inhibitor with an IC50 of 7 uM. ISO-1 exerts anti-cancer effects on PANC-1 cell proliferation, migration and invasion in vitro, and inhibited PANC-1 cell-induced tumour growth in xenograft mice in vivo. | ||
| M9545 | Hydrocortisone Hemisuccinate | GCR |
| Hydrocortisone 21-hemisuccinate | ||
| Hydrocortisone hemisuccinate is an anti-inflammatory agent. | ||
| M10432 | Difelikefalin (CR-845; FE-202845) TFA | Opioid Receptor |
| Disomotide; KORSUVA; MR13A9 TFA | ||
| Difelikefalin (CR-845; FE-202845) TFA is a synthetic peptide and the first-in-class, peripherally-restricted, selective agonist of the κ-opioid receptor (KOR) for studies related to pruritus. | ||
| M11549 | Palifosfamide | DNA Alkylator/Crosslinker |
| Isophosphoramide mustard; IPM; ZIO-201 | ||
| Palifosfamide(Isophosphoramide mustard; IPM; Zio-201) is a new DNA alkylation agent and active metabolite of isocyclophosphamide, which has anticancer activity. | ||
| M13588 | Methotrexate disodium | Antifolate |
| Amethopterin disodium; CL14377 disodium; WR19039 disodium | ||
| Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. | ||
| M17931 | Tenacigenin B, 3-O-β-Allopyranosyl-(1→4)-β-oleandropyranosyl-11-O-isobutyryl-12-O-acetyl- | Others |
| Tenacigenin B, 3-O-β-Allopyranosyl-（1→4）-β-oleandropyranosyl-11-O-isobutyryl-12-O-acetyl- | ||
| M18110 | 4-Isopropyl-6-methyl-1-tetralone | Others |
| 4-Isopropyl-6-methyl-1-tetralone | ||
| M20846 | Hydrocortisone sodium succinate | IL Receptor/Related |
| Hydrocortisone 21-hemisuccinate sodium salt | ||
| Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 μM. Hydrocortisone sodium succinate can bind to glucocorticoid receptor, initiating the transcription of anti-inflammatory and immunosuppressive mediators. | ||
| M21677 | Recombinant Human Follistatin 288 (HEK293, C-6His) | Cytokines and Growth Factors |
| FST; follistatin isoform FST317 | ||
| Follistatin 288 is a secreted glycoprotein that was first identified as a follicle-stimulating hormone inhibiting substance in ovarian follicular fluid . Human follistatin 288 cDNA encodes a 317 amino acid (aa) protein with a 29 aa signal sequence, and a 288 aa mature region. Recombinant Human Follistatin/FST is produced by Mammalian expression system and the target gene encoding Gly30-Asn317 is expressed with a 6His tag at the C-terminus. | ||
| M22503 | A18-Iso5-2DC18 | Liposome |
| A18-Iso5-2DC18 could not only deliver mRNA vaccines robustly but also activate the stimulator of interferon genes (STING) pathway. A18-Iso5-2DC18 is an alkylene ketone-derived. | ||
| M28561 | Afabicin disodium | Antibiotic |
| Debio 1450 disodium; AFN-1720 disodium | ||
| Afabicin (Debio 1450) is the proagent of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci. | ||
| M38953 | Hydrocortisone 17-butyrate | Animal Modeling |
| Hydrocortisone 17-butyrate is an adrenocortico hormone. It can be used to construct animal models of atopic dermatitis. | ||
| M39697 | 15-Isopimarene-8,18-diol | Others |
| 8β,18-Dihydroxysandaracopimar-15-ene | ||
| 15-Isopimarene-8,18-diol (8β,18-Dihydroxysandaracopimar-15-ene) is a compound isolated from Thuja orientalis. | ||
| M39871 | 8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol | Others |
| 8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol is a chemical composition of essential oils from Telekia speciosa. 8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol also shows marked antipro-liferative activity against human cancer cell lines in vitro. | ||
| M40794 | Prednisone acetate | Animal Modeling |
| Prednisone 21-acetate | ||
| Prednisone acetate is the acetate form of Prednisone and a glucocorticoid receptor agonist with anti-inflammatory and immunomodulatory properties. It can be used to construct animal models of Kawasaki disease. | ||
| M41609 | Topoisomerase II inhibitor 16 | Topoisomerase |
| Topoisomerase II inhibitor 16 is a selective, orally active, brain-penetrant and irreversible trypanosomal topoisomerase II inhibitor by stabilizing double-stranded DNA:enzyme cleavage complexes. | ||
| M41613 | Topoisomerase II inhibitor 14 | Topoisomerase |
| Topoisomerase II inhibitor 14 is a potent inhibtor of Topoisomerase II, with anticancer activity. | ||
| M41620 | Topoisomerase II inhibitor 13 | Topoisomerase |
| Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. | ||
| M41621 | Topoisomerase II inhibitor 15 | Topoisomerase |
| Topoisomerase II inhibitor 15 is a Topoisomerase II inhibitor. | ||
| M43879 | Isopropyl unoprostone | Potassium Channel |
| Unoprostone isopropyl ester; UF-021 | ||
| UF-021, an analog of a prostaglandin metabolite and activator of large conductance calcium-activated potassium channels (BK channels), lowers intraocular pressure (IOP) by increasing aqueous humor outflow, and may be used in studies related to glaucoma. | ||
| M54028 | (6S, 9S, 12S)-Benzyl 12-benzyl-9-isobutyl-2, 2-dimethyl-4, 7, 10-trioxo-6-phenethyl-3-oxa-5, 8, 11-triazatridecan-13-oate | Amino Acid Derivatives |
| (6S,9S,12S)-Benzyl 12-benzyl-9-isobutyl-2,2-dimethyl-4,7,10-trioxo-6-phenethyl-3-oxa-5,8,11-triazatridecan-13-oate is a phenylalanine derivative. | ||
| M57442 | 2,6-Diisopropyl-1,4-benzoquinone | Others |
| 2,6-Diisopropyl-1,4-benzoquinone | ||
| M57744 | 4-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | Others |
| 4-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | ||
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