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Difelikefalin (CR-845; FE-202845) TFA

Cat. No. M10432
Difelikefalin (CR-845; FE-202845) TFA Structure
Synonym:

Disomotide; KORSUVA; MR13A9 TFA

Size Price Availability Quantity
2mg USD 350  USD350 In stock
5mg USD 500  USD500 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Difelikefalin (CR-845; FE-202845) TFA is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin TFA produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 793.87
Formula C36H53N7O6.C2HF3O2
CAS Number 1024828-77-0 (free base)
Purity >99%
Solubility DMSO
Water
Storage -20°C, sealed
References

[1] Steven Fishbane, et al. Kidney Int Rep. Randomized Controlled Trial of Difelikefalin for Chronic Pruritus in Hemodialysis Раt iеnts

[2] Steven Fishbane, et al. N Engl J Med. A рhasе 3 Trial of Difelikefalin in Hemodialysis Раt iеnts with Pruritus

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Keywords: Difelikefalin (CR-845; FE-202845) TFA, Disomotide; KORSUVA; MR13A9 TFA supplier, Opioid Receptor, inhibitors

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