About 30 results found for searched term "ID-8" (0.007 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1703 | Deforolimus | mTOR |
| Ridaforolimus, AP23573, MK-8669 | ||
| Deforolimus (also known as AP23573 and MK-8669) is an investigational targeted and small-molecule mTOR inhibitor. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M1710 | Flavopiridol | CDK |
| HMR-1275; Alvocidib; L86-8275 | ||
| Flavopiridol (Alvocidib) is a competitive broad-spectrum CDK inhibitor with IC50 of 30,170,100 nM against CDK1, CDK2 and CDK4, respectively. | ||
| M1845 | LY335979 trihydrochloride | P-glycoprotein |
| Zosuquidar trihydrochloride; RS 33295-198 trihydrochloride | ||
| LY335979 (Zosuquidar trihydrochloride) is a selective Pgp (P-glycoprotein) inhibitor with a Ki of 59 nM. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M1880 | WY 14643 (Pirinixic Acid) | PPAR |
| Pirinixic Acid; NSC 310038 | ||
| WY 14643 (Pirinixic Acid) is a potent and selective, peroxisome proliferator-activated receptor-α (PPARα) agonist. | ||
| M2007 | Romidepsin (FK228) | HDAC |
| FK228; ISTODAX; Depsipeptide; FR 901228; NSC 630176 | ||
| Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M2483 | Cabazitaxel | Others |
| XRP6258; RPR-116258A; taxoid XRP6258 | ||
| Cabazitaxel (XRP6258) is a semi-synthetic derivative of a natural taxoid. | ||
| M2765 | ID-8 | DYRK |
| Id-8 is a DYRK inhibitor that maintains the self-renewal of embryonic stem cells in long-term culture. | ||
| M2838 | Meptazinol hydrochloride | Opioid Receptor |
| IL-22811 hydrochloride; WY-22811 hydrochloride | ||
| Meptazinol is a unique centrally active opioid analgesic, which inhibits [3H]dihydromorphine binding with IC50 of 58 nM. | ||
| M2857 | Nodinitib-1 | NLR |
| ML130; CID-1088438 | ||
| Nodinitib-1 (ML130) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2. | ||
| M2858 | ML167 | CDK |
| CID 44968231 | ||
| ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B. | ||
| M2929 | PF-4981517 | Cytochrome P450 (e.g. CYP17) |
| CYP3cide, PF-04981517 | ||
| PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM, exhibits >500-fold selectivity over CYP3A5 and CYP3A7. | ||
| M2995 | Salinosporamide A | Proteasome |
| (-)-Salinosporamide A; ML 858; NPI 0052; Marizomib | ||
| Salinosporamide A (NPI-0052, Marizomib) is a novel marine derived proteasome inhibitor which inhibits CT-L, C-L, and T-L proteasome activities in human erythrocyte-derived 20S proteasomes with EC50 of 3.5 nM, 430 nM, 28 nM. | ||
| M3213 | Meclizine dihydrochloride | Histamine Receptor |
| Meclozine dihydrochloride; NSC28728 | ||
| Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation properties, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse agonist for hCAR. Phase2. | ||
| M3250 | Vanoxerine dihydrochloride | Dopamine Receptor |
| GBR-12909 dihydrochloride; I893 dihydrochloride | ||
| Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). | ||
| M3379 | Trifluridine | DNA/RNA Synthesis |
| Trifluridine; FTD; 5-Trifluorothymidine; NSC 529182; NSC 75520 | ||
| Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor, and thereby suppressing DNA synthesis. Trifluridine is an antiviral molecule used for research of HSV, rhabdovirus and orthopoxvirus infection. | ||
| M3483 | Flavopiridol hydrochloride | CDK |
| NSC 649890 HCl; Alvocidib hydrochloride; L86 8275 HCl; HMR-1275 HCl | ||
| Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. | ||
| M3684 | Canertinib dihydrochloride | EGFR/HER2 |
| CI-1033 dihydrochloride, Canertinib 2HCl, PD-183805 dihydrochloride | ||
| Canertinib 2HCl is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. | ||
| M3971 | Isosteviol | ROS |
| Ketoisostevic Acid,NSC 231875 | ||
| Isosteviol is a tetracyclic diterpenoid obtained by acid hydrolysis of steviol glycoside extracts isolated from abundant Stevia rebaudiana plants. | ||
| M3998 | Rhein | FTO |
| Cassic acid; Rheic Acid; Monorhein; NSC 38629 | ||
| Rhein, also known as cassic acid, is a substance in the anthraquinone group obtained from rhubarb. | ||
| M4606 | Phloridzin | SGLT |
| Floridzin; NSC 2833 | ||
| Phloridzin is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor. | ||
| M4610 | Raddeanoside-R8 | Others |
| Raddeanoside R8 is a saponin that can be isolated from the fresh roots of anemone. | ||
| M5046 | Imidafenacin (ONO-8025) | AChR/AChE |
| KRP-197; ONO-8025 | ||
| Imidafenacin (ONO-8025) is a urinary antispasmodic of the anticholinergic class.Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors (IC50=4.13 nM). | ||
| M5047 | ML216 | Others |
| CID-49852229 | ||
| ML216 is a potent inhibitor of the DNA unwinding activity of BLM helicase; showing similar IC50s of 3.0 and 0.97 μM for full length BLM and BLM636–1298 respectively. | ||
| M5400 | Alosetron Hydrochloride | 5-HT Receptor |
| GR 68755C, GR 68755 Hydrochloride; GR 68755X Hydrochloride | ||
| Alosetron Hydrochloride is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. | ||
| M5601 | Duloxetine HCl | 5-HT Receptor |
| (S)-Duloxetine hydrochloride; LY-248686 hydrochloride | ||
| Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). | ||
| M5609 | Elacridar (GF120918) | P-glycoprotein |
| GW120918; GG918 | ||
| Elacridar (GF120918) is a potent P-gp (MDR-1) and BCRP inhibitor. | ||
| M5611 | Embelin | IAP |
| Embelic acid; Emberine; NSC 91874 | ||
| Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties. Specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50 = 4.1 uM in a competitive binding assay with Smac peptide). | ||
| M5700 | Idasanutlin (RG-7388) | Mdm2 |
| RG-7388 | ||
| Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM showing improved in vitro binding as well as cellular potency/selectivity. | ||
| M5745 | Lipoamide | Enzymes & Coenzymes |
| (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide | ||
| Lipoamide is a coenzyme, which transfer acetyl and hydrogen in Pyruvate deacylation oxidation Process, used for pharmaceuticals. | ||
| M5795 | Molidustat (BAY 85-3934) | HIF |
| BAY 85-3934 | ||
| Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively. | ||
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