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Lipoamide

Cat. No. M5745
Lipoamide Structure
Synonym:

(±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide

Size Price Availability Quantity
25mg USD 60  USD60 In stock
50mg USD 85  USD85 In stock
100mg USD 135  USD135 In stock
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Quality Control & Documentation
Biological Activity

Lipoamide is a coenzyme, which transfer acetyl and hydrogen in Pyruvate deacylation oxidation Process, used for pharmaceuticals.

Chemical Information
Molecular Weight 205.34
Formula C8H15NOS2
CAS Number 940-69-2
Solubility (25°C) DMSO ≥20 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bryk R, et al. Biochemistry. Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase.

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Keywords: Lipoamide, (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide supplier, Enzymes & Coenzymes, inhibitors, activators


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