About 23 results found for searched term "GABA-IN-1" (0.143 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M43179 | GABA-IN-1 | Others |
| GABA-IN-1 is a GABA inhibitor. | ||
| M1891 | SKF 89976A hydrochloride | GABA Receptor |
| d,l-SKF89976A hydrochloride | ||
| SKF 89976A hydrochloride is a potent GABA uptake inhibitor, selective for GAT-1. | ||
| M4073 | Ginsenoside-Rc | GABA Receptor |
| Panaxoside Rc | ||
| Ginsenoside Rc is one of the major ginsenosides. Ginsenoside Rc enhances GABA receptor A (GABAA) -mediated ion channel (IGABA) currents. Ginsenoside Rc also inhibited TNF-α and IL-1β expression. | ||
| M6092 | Mirogabalin | Calcium Channel |
| DS5565 | ||
| Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium-channel complexes in the CNS. | ||
| M7033 | NNC 05-2090 hydrochloride | Others |
| NNC 05-2090 hydrochloride is a gABA uptake inhibitor; moderately BGT-1 selective. | ||
| M10390 | Aminooxy-acetic acid (AOA) | GABA Receptor |
| 2-(Aminooxy)acetic acid | ||
| Aminooxy-acetic acid (AOA) is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 μM) that induces GABA accumulation in the brain. It also inhibits cystathionine β synthase (CBS) and cystathionine γ lyase (CSE) with IC50 values of 8.5 and 1.1 μM, respectively. Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor. | ||
| M11530 | Guvacine | GABA Receptor |
| Guvacine, an alkaloid found in areca nut, is an effective inhibitor of GABA uptake. Guvacine inhibited rat GAT-1 with IC50 values of 39 μM, 58 μM and 378 μM, respectively. | ||
| M14244 | Furosemide sodium | Others |
| Furosemide sodium is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. | ||
| M19236 | Arecaidine | GABA Receptor |
| Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake. | ||
| M19412 | Anisatin | GABA Receptor |
| Anisatin acts as a picrotoxin-like, non-competitive GABA antagonist. Anisatin suppresses GABA-induced currents in a concentration-dependent manner with an EC50 of ~1.10 μM. | ||
| M27832 | Mirogabalin besylate | Calcium Channel |
| DS 5565 besylate | ||
| Mirogabalin besylate is a selective and orally available ligand for the α2δ subunit of voltage-gated calcium channels, with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively. | ||
| M27944 | Broflanilide | GABA Receptor |
| Broflanilide is a potential insecticide and metabolized to Desmethyl-Broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA Receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM. | ||
| M28621 | (S)-SNAP5114 | GABA Receptor |
| (S)-SNAP5114 is a selective GABA transport inhibitor, with IC50 values of 5 μM and 21 μM for hGAT-3 and rGAT-2, respectively. (S)-SNAP5114 is an anticonvulsant agent. | ||
| M28688 | PF-06372865 | GABA Receptor |
| Darigabat | ||
| PF-06372865 is an orally active, α2/α3/α5 subtype-selective GABAA positive allosteric modulator (PAM). PF-06372865 is a high affinity ligand at GABAA receptors containing α1/α2/α3/α5 subunits (Kis of 2.9 nM, 21 nM, 134 nM for α2, α1 PAM, α2 PAM, respectively), with low affinity for α4/α6 subunits. PF-06372865 can across the blood-brain barrier (BBB). PF-06372865 has anxiolytic activity and has the potential for epilepsy. | ||
| M29887 | BPDBA | GABA Receptor |
| BPDBA is a selective and noncompetitive betaine/GABA transporter (BGT-1) inhibitor with IC50s of 20 μM and 35 μM against human BGT-1 and mouse GAT2, respectively. | ||
| M30145 | Gabapentin enacarbil | Calcium Channel |
| XP-13512 | ||
| Gabapentin enacarbil (XP-13512) is a precursor for the anticonvulsant and analgesic drug gabapentin. | ||
| M30609 | FG 7142 | GABA Receptor |
| ZK 39106; LSU-65 | ||
| FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex. | ||
| M39026 | Chrodrimanin B | GABA Receptor |
| Chrodrimanin B is a potent, non-open-channel-blocking antagonist on B. mori GABAR RDL with an IC50 of 1.13 nM. Chrodrimanin B attenuates the peak current amplitude of the GABA response of RDL with an IC50 of 1.66 nM. | ||
| M39028 | Picrotin | GABA Receptor |
| Picrotin is an active compound, also is one of the composition of picrotoxin (an antagonist of GABAA receptors (GABAARs) and glycine receptors (GlyRs)). Picrotin has sensitivity for GlyRs/b> with IC50 values range from 5.2 μM to 106 μM. Picrotin can be used for the research of neurotransmission. | ||
| M42177 | SCS | GABA Receptor |
| SCS (Salicylidene salicylhydrazide) is a potent, allosteric and selective inhibitor of β1-containing GABAA receptors with an IC50 of 32 nM against α2β1γ1θ by VIPR measurement. | ||
| M42178 | 1-Phenyl-2-pyrrolidinone | GABA Receptor |
| 1-Phenyl-2-pyrrolidinone (1-Phenylpyrrolidin-2-one) is a phenyl analogue of GABA with sedative effect, decreasing the exploratory behavior of rats at 50-100 mg/kg (i.v.). | ||
| M56480 | SCH 50911 | GABA Receptor |
| SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. | ||
| M56473 | SCH 50911 hydrochloride | GABA Receptor |
| SCH 50911 hydrochloride, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. | ||
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