Furosemide sodium is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema.
| Molecular Weight | 352.73 |
| CAS Number | 41733-55-5 |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Seahyung Park, et al. Protocol for sodium depletion and measurement of sodium appetite in mice
[2] Niklas Ayasse, et al. ENaC expression correlates with the acute furosemide-induced K + excretion
[3] B M Santos, et al. Reciprocal interactions between sodium appetite and need-free sugar intake
[4] C Y Porcari, et al. Brain osmo-sodium sensitive channels and the onset of sodium appetite
[5] Robert F Lundy Jr, et al. Furosemide, sodium appetite, and ingestive behavior
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