About 15 results found for searched term "Cisplatin" (0.127 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2223 | Cisplatin | DNA/RNA Synthesis |
| cisplatinum；CDDP；cis-Diamminedichloroplatinum；CPDC | ||
| Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells. | ||
| M43004 | Cisplatin-resistant cells-IN-1 | Others |
| Cisplatin-resistant cells-IN-1 has high cytotoxicity against Cisplatin-resistant cells. | ||
| M2911 | Riviciclib hydrochloride (P276-00) | CDK |
| Riviciclib hydrochloride | ||
| Riviciclib hydrochloride (P276-00) is an effective CDK inhibitor, inhibiting CDK9-CyclinT1, CDK4-cyclin D1, CDK1-Cyclinb with IC50 values of 20 nM, 63 nM, respectively. 79 nM. Riviciclib hydrochloride (P276-00) has anti-tumor activity against Cisplatin resistant cells. | ||
| M3955 | Nedaplatin | DNA/RNA Synthesis |
| NDP | ||
| Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM. | ||
| M7630 | Butein | PDE |
| 2’,3,4,4’-tetrahydroxy Chalcone | ||
| Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator. | ||
| M10628 | Adenosine amine congener | Adenosine Receptor |
| 6-Adac; ADAC | ||
| Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and cisplatin-induced cochlear injury. | ||
| M10667 | UTL-5g | TNF Receptor |
| GBL-5g | ||
| UTL-5g is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hematotoxicity. | ||
| M20804 | ODQ | Others |
| 1H-ODQ | ||
| ODQ (1H-ODQ) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) that enhances the pro-apoptotic effects of cisplatin in human mesothelioma cells. | ||
| M25446 | Sodium thiosulfate | Others |
| Sodium thiosulfate is a chemoprotectant/antioxidant. Sodium Thiosulfate can be used for the protection from Cisplatin-induced hearing loss. | ||
| M28636 | ORC-13661 hydrochloride | Others |
| ORC-13661 hydrochloride is a hair cell protector. ORC-13661 hydrochloride protects sensory hair cells from aminoglycoside and Cisplatin ototoxicity. ORC-13661 hydrochloride is a reversibly mechanoelectrical transducer (MET) channel permeant blocker. | ||
| M30089 | D-α-Tocopherol Succinate | Apoptosis |
| Vitamin E succinate | ||
| D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer. | ||
| M30332 | ZINC05007751 | Others |
| ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9. | ||
| M30766 | CYM-5478 | LPL Receptor |
| CYM-5478 is a potent and highly selective S1P2 agonist with an EC50 of 119 nM in a TGFα-shedding assay. CYM-5478 protects neural-derived cell lines against Cisplatin toxicity. | ||
| M30993 | Kazinol A | Others |
| Kazinol A induces cytotoxic effects in human bladder cancer cells, including the cisplatin-resistant T24R2. | ||
| M45399 | CUR5g | Autophagy |
| CUR5g is a potent autophagy inhibitor that selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g also prevents STX17 from being recruited to autophagosomes through a UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. In addition, CUR5g enhances the in vitro and in vivo anticancer effects of cisplatin in A549 cells. | ||
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