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 About 14 results found for searched term "Cisplatin" (0.124 seconds)

Cat.No.  Name Target
M2223 Cisplatin DNA/RNA Synthesis
cisplatinum;CDDP;cis-Diamminedichloroplatinum;CPDC
Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells.
M43004 Cisplatin-resistant cells-IN-1 Others
Cisplatin-resistant cells-IN-1 has high cytotoxicity against Cisplatin-resistant cells.
M2911 Riviciclib hydrochloride (P276-00) CDK
Riviciclib hydrochloride
Riviciclib hydrochloride (P276-00) is an effective CDK inhibitor, inhibiting CDK9-CyclinT1, CDK4-cyclin D1, CDK1-Cyclinb with IC50 values of 20 nM, 63 nM, respectively. 79 nM. Riviciclib hydrochloride (P276-00) has anti-tumor activity against Cisplatin resistant cells.
M3955 Nedaplatin DNA/RNA Synthesis
NDP
Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM.
M10628 Adenosine amine congener Adenosine Receptor
6-Adac; ADAC
Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and cisplatin-induced cochlear injury.
M10667 UTL-5g TNF Receptor
GBL-5g
UTL-5g is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hematotoxicity.
M20804 ODQ Others
1H-ODQ
ODQ (1H-ODQ) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) that enhances the pro-apoptotic effects of cisplatin in human mesothelioma cells.
M25446 Sodium thiosulfate Others
Sodium thiosulfate is a chemoprotectant/antioxidant. Sodium Thiosulfate can be used for the protection from Cisplatin-induced hearing loss.
M28636 ORC-13661 hydrochloride  Others
ORC-13661 hydrochloride is a hair cell protector. ORC-13661 hydrochloride protects sensory hair cells from aminoglycoside and Cisplatin ototoxicity. ORC-13661 hydrochloride is a reversibly mechanoelectrical transducer (MET) channel permeant blocker.
M30089 D-α-Tocopherol Succinate Apoptosis
Vitamin E succinate
D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer.
M30332 ZINC05007751  Others
ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9.
M30766 CYM-5478  LPL Receptor
CYM-5478 is a potent and highly selective S1P2 agonist with an EC50 of 119 nM in a TGFα-shedding assay. CYM-5478 protects neural-derived cell lines against Cisplatin toxicity.
M30993 Kazinol A  Others
Kazinol A induces cytotoxic effects in human bladder cancer cells, including the cisplatin-resistant T24R2.
M45399 CUR5g Autophagy
CUR5g is a potent autophagy inhibitor that selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g also prevents STX17 from being recruited to autophagosomes through a UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. In addition, CUR5g enhances the in vitro and in vivo anticancer effects of cisplatin in A549 cells.



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