Free shipping on all orders over $ 500

Kazinol A 

Cat. No. M30993
Kazinol A  Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

Kazinol A induces cytotoxic effects in human bladder cancer cells, including the cisplatin-resistant T24R2.

Chemical Information
Molecular Weight 394.5
Formula C25H30O4
CAS Number 99624-28-9
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yunkyeong Lee, et al. Anim Cells Syst (Seoul). Kazinol C from Broussonetia kazinoki stimulates autophagy via endoplasmic reticulum stress-mediated signaling

[2] Jihyun Lim, et al. Br J Pharmacol. Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMP kinase activation

[3] Soojong Park, et al. Phytomedicine. Cytotoxic effects of kazinol A derived from Broussonetia papyrifera on human bladder cancer cells, T24 and T24R2

[4] Yu-Chae Jung, et al. Biochem Biophys Res Commun. Kazinol-E is a specific inhibitor of ERK that suppresses the enrichment of a breast cancer stem-like cell population

[5] Jing-Ru Weng, et al. Phytother Res. Identification of kazinol Q, a natural product from Formosan plants, as an inhibitor of DNA methyltransferase

Related Others Products
Lutonarin

Lutonarin is a antioxidant agent that can be isolated from green barley leaves. Lutonarin (Isoorientin 7-O-glucoside) is a natural product found in aerial part of Silene jeniseensis.
Ethyl glucoside

Ethyl glucoside is a kind of phenolic compound. Ethyl β-D-glucopyranoside can be isolated from ethanolic extract of Scabiosa stellata LS.
Methyl 2,4-dihydroxyphenylacetate

Methyl 2,4-dihydroxyphenylacetate is a natural product isolated from Nigella damascena seeds with selective phytotoxic effects.
Magnesium Lithospermate B

Magnesium Lithospermate B is a derivative of caffeic acid tetramer extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroinflammation and attenuates neurodegeneration.
5-O-Methylvisamminol

5-O-Methylvisamminol, a (furo) chromone identified in the extract of T. glauca. 5-O-Methylvisamminol is useful in (chemical) phylogeny and is a possible excellent chemotaxonomic marker for Apiaceae.
  Catalog
Abmole Inhibitor Catalog




Keywords: Kazinol A  supplier, Others, inhibitors, activators

 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.