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Geniposidic acid is an effective anticancer and radioprotection agent. Geniposidic?acid might be a more potent tumor growth inhibitor than geniposide (GP) when combined with the X-irradiation, though there was no significant synergetic effect on their combined antitumor activity. In a study, collagen synthesis was stimulated by the administration of a hot water extract from the leaves of Eucommia ulmoides OLIVER, Eucommiaceae (Du-Zhong leaves) in false aged model rats. The administration of geniposidic?acid stimulated collagen synthesis in aged model rats.
 |
Source | J Ethnopharmacol (2016). Figure 6. Geniposidic acid |
| Method | Histopathological examination | |
| Cell Lines | rat model | |
| Concentrations | 50 mg/kg | |
| Incubation Time | 48h | |
| Results | Samples from the GPA pretreated before ANIT treated group exhibited significantly reduced liver damage. |
 |
Source | J Ethnopharmacol (2016). Figure 4. Geniposidic acid |
| Method | constituents of bile determined | |
| Cell Lines | rat model | |
| Concentrations | 100, 50 and 25 mg/kg | |
| Incubation Time | 48h | |
| Results | GPA (100, 50 and 25 mg/kg B. W.) groups showed significant (P<0.01 or 0.05) reduced inbile biochemical indicators TBA, TB and DB. |
| Cell Experiment | |
|---|---|
| Cell lines | Human umbilical vein ECs |
| Preparation method | About 50 ml of geniposidic acid (25, 50, and 100 mg/ml) were added into each upper chamber of the Transwell chambers with two sub-wells for each dose group. They were cultured in an incubator thermostat with the condition of 5% CO2 and saturated humidity for 24 h. |
| Concentrations | 25, 50, and 100 mg/ml |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Healthy male New Zealand rabbits |
| Formulation | water |
| Dosages | 80, 160, and 240 mg/kg |
| Administration | oral |
| Molecular Weight | 374.34 |
| Formula | C16H22O10 |
| CAS Number | 27741-01-1 |
| Solubility (25°C) | DMSO 11 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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