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ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9.
| Molecular Weight | 304.3 |
| Formula | C18H12N2O3 |
| CAS Number | 591239-68-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 8.33 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | 4°C, protect from light |
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