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Adenosine amine congener

Cat. No. M10628
Adenosine amine congener Structure

6-Adac; ADAC

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and cisplatin-induced cochlear injury. Adenosine amine congener (ADAC) mitigates noise-induced hearing loss in a dose- and time-dependent manner, but further studies are required to establish its translation as a clinical otological treatment. Adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in the 3-nitropropionic acid model of neurotoxicity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 576.60
Formula C28H32N8O6
CAS Number 96760-69-9
Purity >99%
Solubility DMSO ≥ 10 mg/mL
Storage 2-8°C, protect from light, dry, sealed

[1] Srdjan M Vlajkovic, et al. Biomed Res Int . Adenosine amine congener as a cochlear rescue agent

[2] Srdjan M Vlajkovic, et al. Purinergic Signal . Adenosine amine congener mitigates noise-induced cochlear injury

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Keywords: Adenosine amine congener, 6-Adac; ADAC supplier, Adenosine Receptor, inhibitors

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