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Norisoboldine

Cat. No. M4497
Norisoboldine Structure
Size Price Availability Quantity
5mg USD 80  USD80 In stock
10mg USD 130  USD130 In stock
20mg USD 220  USD220 In stock
50mg USD 440  USD440 In stock
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Quality Control & Documentation
Biological Activity

Norisoboldine is an isoquinoline alkaloid which acts as an AhR agonist.

Product Citations
Chemical Information
Molecular Weight 313.35
Formula C18H19NO4
CAS Number 23599-69-1
Solubility (25°C) DMSO 10 mM
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dandan Xing, et al. The protective effects of propofol against renal ischemia-reperfusion injury are potentiated by norisoboldine treatment via inhibition of oxidative stress pathways

[2] Qi Chen, et al. Norisoboldine Attenuates Sepsis-Induced Acute Lung Injury by Modulating Macrophage Polarization via PKM2/HIF-1α/PGC-1α Pathway

[3] Lan Chang, et al. Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells

[4] Mincong Huang, et al. Application of a DSS colitis model in toxicologically assessing norisoboldine

[5] Qi Lv, et al. Norisoboldine, a natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and subsequent NAD +/SIRT1/SUV39H1/H3K9me3 signaling pathway

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