About 30 results found for searched term "Chymotrypsin" (0.148 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9708 | Chymotrypsin | Enzymes & Coenzymes |
| α-Chymotrypsin | ||
| α-Chymotrypsin is a serine peptidase and has 241 amino acid residues contained in three polypeptide chains (A chain-13 residues, B chain-131 residues, and C chain-97 residues) linked by disulfide bridges. | ||
| M52519 | Chymotrypsinogen | Serine/Threonine Protease |
| Chymotrypsinogen is an inactive precursor of Chymotrypsin. | ||
| M2071 | ONX-0914 | Proteasome |
| PR-957 | ||
| Onx-0914 (PR-957) is a selective inhibitor of low molecular weight polypeptide 7 (LMP7), a chymotrypsin subunit of the immune proteasome. Onx-0914 blocks cytokine production and reduces the progression of experimental arthritis. Onx-0914 is a non-competitive irreversible inhibitor of mycobacterium proteasome (Ki=5.2 μM). Onx-0914 activates latent HIV-1 through HF-1-mediated p-TEFb activation. | ||
| M2122 | MLN9708 | Proteasome |
| ixazomib citrate | ||
| MLN9708 is a novel orally bioactive proteasome inhibitor, inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC50 value of 3.4 nM. | ||
| M2193 | Epoxomicin | Proteasome |
| BU 4061T | ||
| Epoxomicin (BU-4061T) is a cell-permeable, selective and irreversible proteasome inhibitor with an IC50 value of 4 nM. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. | ||
| M2285 | MLN2238 | Proteasome |
| Ixazomib | ||
| MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively. | ||
| M3476 | CEP-18770 | Proteasome |
| Delanzomib | ||
| CEP-18770 is an orally active inhibitor of the chymotrypsin-like activity of proteasome with IC50 of 3.8 nM, with only marginal inhibition of the tryptic and peptidylglutamyl activities of the proteosome. | ||
| M3636 | Leupeptin hemisulfate | Cathepsin |
| Leupeptin hemisulfate hemisulfate is the reversible inhibitor of lysosomal serine and cysteine proteinases; Leupeptin; inhibition of cathepsin B(Ki=6 nM), calpain(Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 μM) and kallikrein (Ki=19 μM) had no effect on chymotrypsin, elastase, renin, or pepsin. | ||
| M3884 | Celastrol | Proteasome |
| Tripterin; Tripterine; CEL | ||
| Celastrol (Tripterin) is a potent antioxidant and anti-inflammatory agent, as well as a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. | ||
| M4985 | VR23 | Proteasome |
| VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes (IC50 = 1 nM), chymotrypsin-like proteasomes (IC50 = 50-100 nM), and caspase-like proteasomes (IC50 = 3 μM). | ||
| M5219 | AEBSF HCl | Serine/Threonine Protease |
| AEBSF hydrochloride | ||
| AEBSF HCl is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. | ||
| M9318 | Chymostatin | Cathepsin |
| Chymostatin is a chymotryptase-like serine proteases inhibitor, with Ki values of 9.36 and 13.1 nM for chymotrypsin and chymase, respectively. | ||
| M11508 | Isoginkgetin | MMP |
| Isoginkgetin is a naturally occurring diflavone with antitumor activity. Isoginkgetin directly inhibits chymotrypsin-like, trypsin-like, and caspase - like activities of the 20S proteasome. Isoginkgetin is an inhibitor of MMP-9 and also an inhibitor of pre-mrna Splicing. | ||
| M14516 | Aclacinomycin A hydrochloride | Proteasome |
| Aclarubicin hydrochloride | ||
| Aclacinomycin A hydrochloride (Aclarubicin hydrochloride), a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. | ||
| M14519 | ONX-0914 TFA | Proteasome |
| PR-957 TFA | ||
| ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. | ||
| M20599 | PI-1840 | Proteasome |
| PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor with IC50 of 27 nM with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L). | ||
| M21684 | Recombinant Human MMP-3 (HEK293, C-6His) | Enzymes & Regulators |
| Matrix metalloproteinase-3 | ||
| MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes. Recombinant Human Matrix Metalloproteinase-3 is produced by Mammalian expression system and the target gene encoding Tyr18-Cys477 is expressed with a 6His tag at the C-terminus.The proenzyme needs to be activated by Chymotrypsin for an activated form. | ||
| M28190 | MG-115 | Proteasome |
| MG115 | ||
| MG-115 is a potent and reversible proteasome inhibitor, with Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis. | ||
| M29173 | GSK3494245 | Parasite |
| DDD01305143 | ||
| GSK3494245 (DDD01305143) is a potent, orally active, and selective inhibitor of the chymotrypsin-like activity of the parasite proteasome binding in a site sandwiched between the β4 and β5 subunits (IC50=0.16 μM for WT L. donovani proteasomes). GSK3494245 moderately inhibits chymotrypsin-like activity of human proteasome (IC50: purified 26S=13 µM; enriched THP-1 extracts IC50=40µM). GSK3494245 exhibits attractive biological and biosafety properties. | ||
| M40580 | MEDI-4166 | GLP Receptor |
| MEDI-4166 is a novel GLP-1 analog of an anti-preprotein convertase chymotrypsin 9 (PCSK9) monoclonal antibody fused to GLP-1, as well as a GLP-1R agonist, which can be used in cardiovascular disease-related studies. | ||
| M40914 | Rivulariapeptolides 1155 | Serine/Threonine Protease |
| Rivulariapeptolides 1155 is a potent serine protease inhibitor with IC50 values of 41.84 nM, 4.94 nM, and 56.54 nM for chymotrypsin, elastase, and proteinase K, respectively. | ||
| M51113 | Suc-Leu-Leu-Val-Tyr-pNA | Others |
| Suc-Leu-Leu-Val-Tyr-pNA is a chymotrypsin-like chromogenic substrate that can be used to detect chymotrypsin enzymatic activity. | ||
| M51264 | Proteasome-activating peptide 1 | Others |
| Proteasome-activating peptide 1 is a peptide, which increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. | ||
| M52515 | Suc-AAPA-pNA | Serine/Threonine Protease |
| Suc-AAPA-pNA is a substrate of chymotrypsin Aα. | ||
| M52524 | N-Benzoyl-L-tyrosine p-nitroanilide | Serine/Threonine Protease |
| N-Benzoyl-L-tyrosine p-nitroanilide is a chymotrypsin substrate. | ||
| M52532 | Z-LLF-CHO | Proteasome |
| Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (Ki = 460 nM). | ||
| M52534 | Z-Leu-Leu-Leu-AMC | Proteasome |
| Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome. | ||
| M52538 | Z-Leu-Leu-Tyr-COCHO | Proteasome |
| Z-Leu-Leu-Tyr-COCHO is a potent chymotrypsin-like activity inhibitor with a Ki value of 3.0 nM. | ||
| M52539 | Suc-Gly-Gly-Phe-pNA | Proteasome |
| Suc-Gly-Gly-Phe-pNA is the chymotrypsin substrate with an Km value of 1.6 mM. | ||
| M52543 | Suc-Ala-Ala-Pro-Phe-SBzl | Proteasome |
| Suc-Ala-Ala-Pro-Phe-SBzl can be used as the substrate of rat intestinal mast cell protease (RMCP I), rat skeletal muscle mast cell protease (RMCP II) and Chymotrypsin. | ||
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