Free shipping on all orders over $ 500

PI-1840

Cat. No. M20599

All AbMole products are for research use only, cannot be used for human consumption.

PI-1840 Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor with IC50 of 27 nM with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L).

Chemical Information
Molecular Weight 394.47
Formula C22H26N4O3
CAS Number 1401223-22-0
Solubility (25°C) DMSO 78 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yajun Yang, et al. Bioorg Med Chem Lett. Design, synthesis and biological evaluation of triaryl compounds as novel 20S proteasome inhibitors

[2] Yuxi Chen, et al. Oncol Rep. Non‑covalent proteasome inhibitor PI‑1840 induces apoptosis and autophagy in osteosarcoma cells

[3] Jianjun Yu, et al. Eur J Med Chem. Design, synthesis, and biological evaluation of novel phenol ether derivatives as non-covalent proteasome inhibitors

[4] Aslamuzzaman Kazi, et al. J Biol Chem. Discovery of PI-1840, a novel noncovalent and rapidly reversible proteasome inhibitor with anti-tumor activity

[5] Sevil Ozcan, et al. J Med Chem. Oxadiazole-isopropylamides as potent and noncovalent proteasome inhibitors

Related Proteasome Products
Proteasome inhibitor IX

Proteasome inhibitor IX (PS-IX; AM114) is a Chalcone derivative and a chymotrypsin-like activity of the 20S proteasome inhibitor with an IC50 value of ~1 μM.
NIC-0102

NIC-0102 is an orally potent proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammasome activation.NIC-0102 showed potent anti-inflammatory effects in vivo in a DSS-induced ulcerative colitis model. In addition, NIC-0102 inhibited the production of pro-IL-1β.
Ac-WLA-AMC

Ac-WLA-AMC is a specific 20S constitutive proteasome β5 fluorogenic substrate.
Ac-Nle-Pro-Nle-Asp-AMC

Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome.
PR-39

PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor.
  Catalog
Abmole Inhibitor Catalog




Keywords: PI-1840 supplier, Proteasome, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.