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Aclacinomycin A hydrochloride

Cat. No. M14516

All AbMole products are for research use only, cannot be used for human consumption.

Aclacinomycin A hydrochloride Structure
Synonym:

Aclarubicin hydrochloride

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Quality Control & Documentation
Biological Activity

Aclacinomycin A hydrochloride (Aclarubicin hydrochloride), a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II. An effective anthracycline chemotherapeutic agent for hematologic cancers and solid tumors.

Chemical Information
Molecular Weight 848.33
CAS Number 75443-99-1
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage 2-8°C, protect from light, dry, sealed
References

[1] Haotian Li, et al. Antimicrobial compounds from an FDA-approved drug library with activity against Streptococcus suis

[2] Qingyu Xu, et al. Epigenetic modifier gene mutations-positive AML patients with intermediate-risk karyotypes benefit from decitabine with CAG regimen

[3] S Mori, et al. [Studies on the stability of aclacinomycin hydrochloride. I. Stability of solution of aclacinomycin hydrochloride (author's transl)]

[4] G K Poochikian, et al. Stability of anthracycline antitumor agents in four infusion fluids

[5] S Mori, et al. Physiochemical properties and stability of aclacinomycin A hydrochloride

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Keywords: Aclacinomycin A hydrochloride, Aclarubicin hydrochloride supplier, Proteasome, inhibitors, activators

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