About 30 results found for searched term "BO-1" (0.019 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1686 | Bortezomib (PS-341) | Proteasome |
| Velcade; PS-341; LDP 341; MG 341; NSC 681239 | ||
| Bortezomib (PS-341) is a highly selective proteasome inhibitor with a ki value of 6nM. | ||
| M1757 | XL-184 | c-Met |
| Cabozantinib, BMS-907351，Cabometyx | ||
| XL184 is a small molecule inhibits multiple receptor tyrosine kinases, specifically MET and VEGFR2 with IC50 values of 0.035 and 1.8 nM for VEGFR2 and Met respectively. | ||
| M2218 | Ribociclib (LEE011) | CDK |
| Ribociclib | ||
| Ribociclib (LEE011) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is 1000 times less active against cyclin B/CDK1 complex. | ||
| M3678 | CEP-11981 | VEGFR/PDGFR |
| BOL 303213X | ||
| CEP-11981 is an oral vascular endothelial growth factor (VEGF) tyrosine kinase inhibitor. | ||
| M1333 | Talabostat mesylate | Dipeptidyl Peptidase |
| BXCL701 mesylate; Val-boroPro mesylate; PT100 mesylate | ||
| Talabostat mesylate (Val-boroPro mesylate; PT100 mesylate) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC50 < 4 nM; Ki = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) (IC50 = 560 nM). | ||
| M4647 | Phorbol 12-myristate 13-acetate | PKC |
| PMA, TPA, 12-O-tetradecanoyl-phorbol-13-acetate; 12,13-tetradecanoyl phorbol acetate | ||
| Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and protein kinase C (PKC) activator, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM. | ||
| M4648 | 12-O-Tiglylphorbol-13-isobutyrate | Others |
| The compound is extracted from Croton tiglium dried fruit. | ||
| M4822 | Eltrombopag Olamine | Thrombopoietin/Thrombin |
| Eltrombopag diethanolamine salt; SB-497115GR | ||
| Eltrombopag olamine is a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. | ||
| M4889 | Ribociclib succinate (LEE011 succinate) | CDK |
| Ribociclib succinate | ||
| Ribociclib succinate (LEE011 succinate) is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. | ||
| M5479 | Carsalam | Others |
| Carbonylsalicylamide; 2H-1,3-Benzoxazine-2,4(3H)-dione | ||
| Carsalam (Carbonylsalicylamide) is a non-steroidal anti-inflammatory compound. | ||
| M5545 | Cytidine | DNA/RNA Synthesis |
| Cytosine β-D-riboside; Cytosine-1-β-D-ribofuranoside | ||
| Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA. | ||
| M5806 | Nandrolone decanoate | Androgen Receptor |
| Deca Durabolin, 19-Nortestosterone decanoate, Retabolil | ||
| Nandrolone Decanoate is a mild form of an anabolic steroid. | ||
| M5836 | Orotic acid (6-Carboxyuracil) | DNA/RNA Synthesis |
| 6-Carboxyuracil; Vitamin B13 | ||
| Orotic acid(6-Carboxyuracil) is a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. | ||
| M6289 | Erythromycin cyclocarbonate | Antibiotic |
| Erythromycin cyclic carbonate; Erythromycin A 11,12-carbonate | ||
| Erythromycin Cyclocarbonate, derivative of Erythromycin, inhibits protein synthesis of bacteria by binding to the 50S ribosome. | ||
| M7136 | Phorbol 12,13-dibutyrate | PKC |
| Phorbol 12,13-dibutyrate is a protein kinase C activator. | ||
| M8723 | PBOX-15 | Others |
| PBOX-15 belongs to a group of tubulin-targeting pyrrolo-1,5-benzoxazepine (PBOX) compounds that potently induce apoptosis in a wide spectrum of cancer cells, including those originating from the four main types of leukemia and those exhibiting multi-drug resistance (IC50 = 155 nM/HL60-MDR1, 252 nM/HL60-ABCG2, 210 nM/HL60). | ||
| M8766 | Atrasentan hydrochloride | Endothelin Receptor |
| ABT-627 hydrochloride; Abbott 147627 | ||
| Atrasentan hydrochloride (ABT-627 hydrochloride) is a potent, orally active, selective endothelin A (ETA) receptor antagonist that inhibits ETA activity and blocks endothelin-induced cellular proliferation with an IC50 value of 0.0551 nM. It can be used in studies related to prostate cancer as well as IgA nephropathy (IgAN). It can be used in prostate cancer and IgA nephropathy (IgAN) related studies. | ||
| M8964 | Thymidine | DNA/RNA Synthesis |
| DThyd; Deoxyribothymidine; NSC 21548 | ||
| Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. | ||
| M9133 | AKBA | Lipoxygenase |
| 3-O-Acetyl-11-keto-β-boswellic acid; Acetyl-11-keto-β-boswellic acid | ||
| AKBA is an active triterpenoid compound from the extract of Boswellia serrata and Boswellia carteri Birdw, exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase. | ||
| M10433 | Bozitinib (PLB-1001) | c-Met |
| CBT-101; APL-101; CBI-3103; Vebreltinib | ||
| Bozitinib (PLB-1001; CBT-101) is a highly selective, blood-brain barrier permeable c-MET kinase inhibitor. | ||
| M10582 | Rbin-1 | Phosphatase |
| Ribozinoindole-1 | ||
| Rbin-1 (ribozinoindole-1) is a potent and reversible inhibitor of Midasin (Mdn1), an enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) protein family (GI50 value 136 nM in wild-type cells). | ||
| M13602 | Abemaciclib metabolite M18 hydrochloride | CDK |
| LSN3106729 hydrochloride | ||
| Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib , is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader. | ||
| M14324 | Tofacitinib metabolite-1 | Others |
| Tofacitinib metabolite-1 is a metabolite of Tofacitinib, a JAK inhibitor. Tofacitinib metabolite-1 can be used in the pharmacokinetics and metabolism studies of tofacitinib. | ||
| M14402 | Pimelic acid | Metabolite/Endogenous Metabolite |
| Heptanedioic acid; 1,5-Pentanedicarboxylic acid; 1,7-Heptanedioic acid | ||
| Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine. | ||
| M15015 | Recombinant Human Carbonic Anhydrase 1/CA1 (E.coli,C-6His) | Cytokines and Growth Factors |
| Carbonate Dehydratase I; Carbonic Anhydrase B | ||
| The recombinant human Carbonic Anhydrase 1/CA1 protein was produced by our escherichia coli expression system, and the target gene encoding ALA2-PHE261 was expressed at the C-terminal as 6His marker. Accession # : P00915. | ||
| M16377 | 4β-Carboxy-19-nortotarol | Diterpenoids |
| 4β-Carboxy-19-nortotarol | ||
| M17469 | 11-Hydroxybisabola-1,3,5-trien-9-one | Sesquiterpenoids |
| 11-Hydroxybisabola-1,3,5-trien-9-one | ||
| M17476 | 1-Hydroxybisabola-2,10-dien-4-one | Sesquiterpenoids |
| 1-Hydroxybisabola-2,10-dien-4-one | ||
| M17497 | Bisabola-3,10-dien-2-one | Sesquiterpenoids |
| Bisabola-3,10-dien-2-one | ||
| M17923 | Cyclohexanecarboxylic acid, 3-[[ (2E)-3-[4-(D-glucopyranosyloxy)-3-hydroxyphenyl]-1-oxo-2-propen-1-yl]oxy]-1,4,5-trihydroxy-, (1S,3R,4R,5R)- | Others |
| Cyclohexanecarboxylic acid, 3-[[（2E）-3-[4-（D-glucopyranosyloxy）-3-hydroxyphenyl]-1-oxo-2-propen-1-yl]oxy]-1,4,5-trihydroxy-, （1S,3R,4R,5R）- | ||
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