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AKBA

Cat. No. M9133
AKBA Structure
Synonym:

3-O-Acetyl-11-keto-β-boswellic acid; Acetyl-11-keto-β-boswellic acid

Size Price Availability Quantity
5mg USD 150  USD150 In stock
10mg USD 270  USD270 In stock
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Quality Control & Documentation
Biological Activity

AKBA is an active triterpenoid compound from the extract of Boswellia serrata and Boswellia carteri Birdw, exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase. AKBA reduced the impact of proliferative retinopathies, protecting neurons against ischemic injury involving the Nrf2/HO-1 pathway. AKBA significantly inhibited human colon adenocarcinoma growth, showing arrest of the cell cycle in G1-phase and induction of apoptosis.

In vivo, AKBA significantly prevented the formation of intestinal adenomatous polyps without toxicity to mice. AKBA administration in mice effectively delayed the growth of HT-29 xenografts without signs of toxicity.

Chemical Information
Molecular Weight 512.72
Formula C32H48O5
CAS Number 67416-61-9
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rehman NU, et al. Phytochem Anal. Quantification of AKBA in Boswellia sacra Using NIRS Coupled with PLSR as an Alternative Method and Cross-Validation by HPLC.

[2] Niphadkar SS, et al. Prep Biochem Biotechnol. Adsorption kinetics, isotherm, and thermodynamics studies of acetyl-11-keto-β-boswellic acids (AKBA) from Boswellia serrata extract using macroporous resin.

[3] Meka B, et al. Bioorg Med Chem. Synthesis of new analogs of AKBA and evaluation of their anti-inflammatory activities.

[4] Mannino G, et al. Molecules. Quantitative Determination of 3-O-Acetyl-11-Keto-βBoswellic Acid (AKBA) and Other Boswellic Acids in Boswellia sacra Flueck (syn. B. carteri Birdw) and Boswellia serrata Roxb.

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Keywords: AKBA, 3-O-Acetyl-11-keto-β-boswellic acid; Acetyl-11-keto-β-boswellic acid supplier, Lipoxygenase, inhibitors, activators


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