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AKBA

Cat. No. M9133
AKBA Structure
Synonym:

3-O-Acetyl-11-keto-β-boswellic acid; Acetyl-11-keto-β-boswellic acid

Size Price Availability Quantity
5mg USD 144  USD144 In stock
10mg USD 255  USD255 In stock
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Quality Control
Biological Activity

AKBA is an active triterpenoid compound from the extract of Boswellia serrata and Boswellia carteri Birdw, exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase. AKBA reduced the impact of proliferative retinopathies, protecting neurons against ischemic injury involving the Nrf2/HO-1 pathway. AKBA significantly inhibited human colon adenocarcinoma growth, showing arrest of the cell cycle in G1-phase and induction of apoptosis.

In vivo, AKBA significantly prevented the formation of intestinal adenomatous polyps without toxicity to mice. AKBA administration in mice effectively delayed the growth of HT-29 xenografts without signs of toxicity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 512.72
Formula C32H48O5
CAS Number 67416-61-9
Purity 100.00%
Solubility DMSO 10 mM
Storage at -20°C
References

[1] Rehman NU, et al. Phytochem Anal. Quantification of AKBA in Boswellia sacra Using NIRS Coupled with PLSR as an Alternative Method and Cross-Validation by HPLC.

[2] Niphadkar SS, et al. Prep Biochem Biotechnol. Adsorption kinetics, isotherm, and thermodynamics studies of acetyl-11-keto-β-boswellic acids (AKBA) from Boswellia serrata extract using macroporous resin.

[3] Meka B, et al. Bioorg Med Chem. Synthesis of new analogs of AKBA and evaluation of their anti-inflammatory activities.

[4] Mannino G, et al. Molecules. Quantitative Determination of 3-O-Acetyl-11-Keto-βBoswellic Acid (AKBA) and Other Boswellic Acids in Boswellia sacra Flueck (syn. B. carteri Birdw) and Boswellia serrata Roxb.

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Keywords: AKBA, 3-O-Acetyl-11-keto-β-boswellic acid; Acetyl-11-keto-β-boswellic acid supplier, Lipoxygenase, inhibitors

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