About 30 results found for searched term "Lipoxygenase" (0.197 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2332 | Zileuton | Lipoxygenase |
| A 64077; Abbott 64077 | ||
| Zileuton is an orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB4 synthesis with IC50 values of 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively. | ||
| M4388 | Rosmarinic-acid | IκB/IKK |
| Labiatenic acid | ||
| Rosmarinic acid (RA, Rosemary acid) is a naturally occurring hydroxylated compound, it has the ability to block complement fixation, inhibit lipoxygenase and cyclooxygenase activity and inhibit the expression of CCL11 and CCR3 by suppressing the IKK-β activity in NF-κB activation signaling. | ||
| M4714 | Picrinine | Lipoxygenase |
| Picrinine is an Akuammiline alkaloid isolated from the leaves of Alstonia Scholaris. Picrinine shows anti-inflammatory activity by inhibiting 5-lipoxygenase. | ||
| M5170 | U73122 | Phospholipase |
| U-73122 | ||
| U73122 is a potent inhibitor of phospholipase C, phospholipase A2 and 5-LO (5-lipoxygenase). | ||
| M5312 | Anacardic Acid | Histone Acetyltransferase |
| 6-pentadecylsalicylic Acid | ||
| Anacardic Acid is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity, prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition. | ||
| M6331 | 2-TEDC | Lipoxygenase |
| 2-TEDC is a 5-, 12-, 15-Lipoxygenase inhibitor. | ||
| M6492 | BAY-X 1005 | Others |
| BAY-X 1005 is a orally active 5-lipoxygenase activating protein (FLAP) inhibitor. | ||
| M6545 | BW-B 70C | Others |
| BW-B 70C is a 5-Lipoxygenase inhibitor. | ||
| M7104 | PD 146176 | Ferroptosis |
| PD146176 | ||
| PD 146176 is a selective 15-lipoxygenase inhibitor. | ||
| M7964 | Nordihydroguaiaretic acid | Lipoxygenase |
| NDGA | ||
| Lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure. | ||
| M7983 | 9,12-Octadecadiynoic acid | Others |
| Potent cyclooxygenase and lipoxygenase inhibitor. | ||
| M8115 | PF-4191834 | Others |
| PF-4191834 a selective, non-redox, non-iron chelating competitive inhibitor of 5-lipoxygenase effective in inflammation and pain. | ||
| M8251 | CJ-13610 | Others |
| CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC50 = 70 nM). | ||
| M8370 | NCTT-956 | Others |
| NCTT-956 is a very potent, specific inhibitor of 12-lipoxygenase (12-LO) activity, with an IC50 of 800 nM, no activity against 5-LO and greater than 25-fold selectivity over 15-LO. | ||
| M8506 | ML351 | Lipoxygenase |
| ML351 is a cell penetrant, selective and highly potent human lipoxygenase-12/15 (15-Lipoxygenase-1, 12/15-LOX) inhibitor that exhibits protective effects against oxidative glutamate toxicity in mouse neuronal HT22 cells. | ||
| M8805 | Terameprocol | Others |
| Terameprocol is a synthetic derivative of NDGA, a non-selective lipoxygenase inhibitor. | ||
| M9133 | AKBA | Lipoxygenase |
| 3-O-Acetyl-11-keto-β-boswellic acid; Acetyl-11-keto-β-boswellic acid | ||
| AKBA is an active triterpenoid compound from the extract of Boswellia serrata and Boswellia carteri Birdw, exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase. | ||
| M10499 | FPL 62064 | Lipoxygenase |
| FPL62064 | ||
| FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. | ||
| M11119 | 11-Keto-beta-boswellic acid | Lipoxygenase |
| 11-Keto-β-boswellic acid | ||
| 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenoid acid derived from the oleoresin of the bark of the Boswellia serrate tree commonly known as Indian Frankincense. 11-Keto-beta-boswellic acid has anti-inflammatory activity, mainly due to inhibition of 5-lipoxygenase (5-lipoxygenase; Activation of 5-LOX), leukotriene, activation of NF-κB and production of tumor necrosis factor α. | ||
| M14087 | Diflapolin | Epoxide Hydrolase |
| Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. | ||
| M14459 | Docebenone | Lipoxygenase |
| AA 861 | ||
| Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. | ||
| M14460 | ML355 | Lipoxygenase |
| ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties. | ||
| M15061 | AZD5718 | Lipoxygenase |
| Atuliflapon | ||
| AZD5718 (atuliflapon) is a 5-lox activating protein (FLAP) inhibitor that attenuates the 5-lipoxygenase pathway and reduces pro-inflammatory and vasoactive leukotriene (LT) production at an in vitro maximum 50% inhibitory concentration (IC50) of 39nM. | ||
| M19155 | Entadamide A | Lipoxygenase |
| Entadamide A is a natural product found in Entada rheedei and Entada gigas. Entadamide A inhibited the 5-lipoxygenase activity of RBL-1 cells at 10(-4) g/ml. | ||
| M20500 | Phenidone | COX |
| 1-phenyl-3-pyrazolidinone | ||
| Phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer. | ||
| M28263 | Quiflapon | Lipoxygenase |
| MK-591 | ||
| Quiflapon (MK-591) is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50 of 1.6 nM in a FLAP binding assay. Quiflapon is also a potent and orally active Leukotriene biosynthesis (LT) inhibitor, shows IC50 values of 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively. Quiflapon induces cell apoptosis. | ||
| M28508 | Quiflapon sodium | Lipoxygenase |
| MK-591 sodium | ||
| Quiflapon sodium (MK-591 sodium) is a selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor. Quiflapon sodium is an orally active Leukotriene biosynthesis inhibitor. Induces apoptosis. | ||
| M29823 | Masoprocol | Lipoxygenase |
| meso-Nordihydroguaiaretic acid; meso-NDGA | ||
| Masoprocol is a potent, orally active lipoxygenase inhibitor and Nrf2 pathway activator that reduces glucose and hepatic triglyceride concentrations in vivo, and has antihyperglycemic activity that may be useful in studies related to type II diabetes. | ||
| M30519 | Canniprene | Prostaglandin Receptor |
| Canniprene, an isoprenylated bibenzyl unique to Cannabis sativa, is a potent inhibitor of 5-lipoxygenase (5-LO) activity (IC50=0.4 μM) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE2; IC50=10 μM). Canniprene inhibits the production of inflammatory eicosanoids and affects the generation of prostaglandins. | ||
| M30835 | Lipoxin A4 | IL Receptor/Related |
| LXA4 | ||
| Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM. | ||
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